冠心病患者血清内脏脂肪素水平的变化及其影响因素的研究

目的:了解冠心病患者血清内脏脂肪素(visfatin)水平的变化及其影响因素.方法:观测70例冠心病患者(冠心病组)和18例健康对照(对照组)血清内脏脂肪素水平和其他临床生化指标,分析血清内脏脂肪素的变化及其影响因素.结果:冠心病组血清内脏脂肪素显著高于对照组；合并糖尿病的冠心病患者显著高于没有合并糖代谢异常的患者；冠心病患者血清内脏脂肪素与体重指数、高密度脂蛋白胆固醇(HDL-C)、胰岛素抵抗指数(HOMA-RI)显著正相关,与甘油三酯显著负相关；多因素回归分析显示,胰岛素抵抗指数和体重指数是血清内脏脂肪素的独立影响因素.结论:冠心病患者血清内脏脂肪素水平显著升高,胰岛素抵抗指数和体重指数是其升高的独立影响因素.

Serum Visfatin and its Influencing Factors in Patients With Coronary Artery Disease

Objective: To explore the changes of serum visfatin and its influencing factors in patients with coronary artery disease(CAD). Methods: Our study included two groups,CAD group,n=70 and Control group,n=18 healthy subjects.Serum visfatin level and other biochemical parameters were examined and compared between two groups. Results:The serum level of visfatin in CAD group was significantly higher than that in Control group.The visfatin level in CAD combined with type 2 diabetes mellitus was much higher than the patients without abnormal glucose metabolism.Visfatin in CAD patients was positively related to body mass index(BMI),high density lipoprotein cholesterol(HDL-C) and homeostasis model assessment-insulin resistance(HOMA-RI) index.Visfatin was negatively related to triglyceride.Multiple linear regression analysis presented that HOMA-RI and BMI were the independent influencing factors for visfatin in CAD patients. Conclusion:CAD patients have increased serum visfatin.HOMA-RI and BMI are independent influencing factors for visfatin.