| 特益乳膏的制备及稳定性考察 |
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| 引用本文： | 刘辉,郭苗苗,徐丹,樊荣丹.特益乳膏的制备及稳定性考察[J].中国药房,2012(1):54-56. |
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| 作者姓名： | 刘辉 郭苗苗 徐丹 樊荣丹 |
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| 作者单位： | 广州军区武汉总医院药剂科;湖北中医药大学药学院 |
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| 摘 要： | 目的:研制盐酸特比萘芬硝酸益康唑乳膏(特益乳膏)并考察该制剂的稳定性。方法:采用单因素法优化处方制得特益乳膏并对其在市售包装条件下进行稳定性试验(影响因素试验、加速试验和长期试验)。结果:优化处方组成包括盐酸特比萘芬10g、硝酸益康唑2.5g、白凡士林30g、十八醇10g、硬脂酸60g、三乙醇胺5.4g等(总量1000g),所制样品均匀、细腻、涂展性好;其稳定性各项指标未见明显变化。结论:所制特益乳膏处方合理,在市售包装条件下稳定性良好。
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| 关 键 词： | 特益乳膏 盐酸特比萘芬 硝酸益康唑 制备 稳定性 |
Study on Preparation and Stability of Teyi Cream |
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| LIU Hui,GUO Miao-miao,XU DanDept.of Pharmacy,Wuhan General Hospital of Guangzhou Military Command,Wuhan,China GUO Miao-miao,XU DanCollege of Pharmacy,Hubei University of Traditional Chinese Medicine,Wuhan,China FAN Rong-dan.Study on Preparation and Stability of Teyi Cream[J].China Pharmacy,2012(1):54-56. |
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| Authors: | LIU Hui GUO Miao-miao XU DanDeptof Pharmacy Wuhan General Hospital of Guangzhou Military Command Wuhan China GUO Miao-miao XU DanCollege of Pharmacy Hubei University of Traditional Chinese Medicine Wuhan China FAN Rong-dan |
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| Institution: | LIU Hui,GUO Miao-miao,XU Dan(Dept.of Pharmacy,Wuhan General Hospital of Guangzhou Military Command,Wuhan 430070,China) GUO Miao-miao,XU Dan(College of Pharmacy,Hubei University of Traditional Chinese Medicine,Wuhan 430065,China) FAN Rong-dan(College of Pharmacy,Xianning University,Hubei Xianning 437100,China) |
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| Abstract: | OBJECTIVE:To prepare Terbinafine hydrochloride and econazole nitrate cream(Teyi cream) and to investigate its stability.METHODS:The formulation of Teyi cream was optimized with single factor method.Its stability was studied by plotting the influential factor tests,accelerated test and long-term test.RESULTS:Optimal formulation of Teyi cream composed of terbinafine hydrochloride 10 g,econazole nitrate 2.5 g,albolene 30 g,octadecanol 10 g,octadecanoic acid 60 g,triethanolamine 5.4 g and so on(total amount was 1 000 g),exhibiting uniform ivory ointment.Stability results showed that there were no significant changes in such indexes.CONCLUSION:The formulation of prepared Teyi cream is optimal and has a good stability with package. |
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| Keywords: | Teyi cream Terbinafine hydrochloride Econazole nitrate Preparation Stability |
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