| Abstract: | IT has been claimed that monoamine oxidase inhibitors inhibit the actions of leptazol in experimental animals (Chow & Hendley, 1959; Prockop, Shore & Brodie, 1959; Yen, Salvatore & others, 1962). But other workers have failed to confirm this anticonvulsant action (Kobinger, 1958; Lessin & Parkes, 1959) and some have claimed a proconvulsant effect (Sansome & Dell'Omodarme, 1963; Spoerlein & Ellman, 1961). Reports of the effect of (+)-amphetamine on leptazol convulsions are equally conflicting. Small doses capable of antagonizing electroshock convulsions are described as ineffective against leptazol according to Wolff & Stock (1966), whilst Friebel & Klatt (1959) demonstrated a proconvulsant action. Reserpine enhances the effect of leptazol in animals, the greatest effect appearing to coincide with maximal depletion of tissue amines. If the animals are pretreated with a monoamine oxidase inhibitor before receiving reserpine, however, the subsequent sensitivity of the animal to leptazol is reduced (Pfeifer & Galambos, 1967) or is unaffected (Chen & Bohner, 1961; Spoerlein & Ellman, 1961). We report initial observations during a re-examination of the interaction between leptazol and five representative monoamine oxidase inhibitors. |
