| Abstract: | The effect of immunization with fetal antigens and tumor-specific antigens on the transplantation of SVT2, a BALB/c mouse tumor induced by Simian virus 40 (SV40), has been studied. Hyperimmunization with 5,000 R X-irradiated, syngeneic fetuses of 1–2 weeks' gestation or syngeneic spleen cells gave no protection to SVT2 cell challenge. In contrast, immunization with SV40 or SV40-transformed cells gave a 100- to 1,000-fold protection. These results gave additional evidence that fetal antigens are different from tumor-specific transplantation antigen (TSTA). |
