Effects of aprotinin on hemorrhagic complications in ARDS patients during prolonged extracorporeal CO2 removal |
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| Authors: | Dr. F. Brunet J. P. Mira M. Belghith J. J. Lanore S. Schlumberger P. Toulon J. F. Dhainaut |
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| Affiliation: | (1) Medical Intensive Care Unit, Cochin-Port Royal University, Paris, France;(2) Cardiac Surgery Unit, Foch Hospital, Suresnes, France;(3) Service de Réanimation Médicale, Hôpital Cochin, F-75674 Paris Cedex 14, France |
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| Abstract: | The effects of aprotinin, a broad-based proteinase inhibitor, in the management of hemorrhagic complications during prolonged venovenous extracorporeal CO2 removal in patients with adult respiratory distress syndrome are not evaluated. In two patients, aprotinin infusion was added to heparin to treat bleeding, occurring after few days of bypass and responsible for respiratory and hemodynamic deterioration. After aprotinin infusion (loading dose of 2×106 kIU followed by a continuous infusion of 5×105 kIU/h) combined with heparin, bleeding vanished until the end of bypass. |
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| Keywords: | Aprotinin Adult respiratory distress syndrome Extracorporeal CO2 removal |
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