腹腔液胰淀粉酶水平对急性实验性猴坏死性胰腺炎的病情及预后的判定

目的　研究急性坏死性胰腺炎腹腔液胰淀粉酶在预测胰腺炎胰腺病变及预后中的意义。方法　经猴十二指肠乳头行胰管内插管逆行注射胆汁和胰蛋白酶混合液 ,制成猴急性坏死性胰腺炎模型。结果　猴胰腺炎胰腺病变程度与胰管内注射胆汁和胰蛋白酶混合液的速度、注液量及早期腹腔液胰淀粉酶水平呈正相关 ,随注液速度增快 (3～ 13ml/ min) ,注液量增大 (0 .1～ 1.0 m l/ kg) ,腹腔液胰淀粉酶水平增高 ,胰腺病变程度加重。同时发现猴胰腺炎腹腔液胰淀粉酶 (0 .5 h)水平与生存时间呈负相关 ,相关系数 r=- 0 .88,相关方程为 t=- 9.0 6 In X 12 9.85 ,P<0 .0 1。结论　急性坏死性胰腺炎早期腹腔液胰淀粉酶水平可以预示胰腺炎病变严重程度及预后。

Prediction of Peritoneal Fluid Pancreatic Amylase to Histopathological Change and Prognosis of Acute Experimental Necrotic Pancreatitis of Monkey

OBJECTIVE: To observe the significance of peritoneal fluid pancreatic amylase in predicting the degree of histopathological change and prognosis of acute necrotic pancreatitis (ANP) of monkey. METHODS: Injection of the mixture of bile and trypsin into the pancreatic duct set up ANP monkey model. RESULTS: The severity of ANP depended on the injection rate and volume, in correlation to the peritoneal fluid pancreatic amylase (PF Amylase) in the early stage of ANP. With the rate (3-13 ml/min) and volume (0.1-1.0 ml/kg) of injection increase, the PF Amylase in the early stage of the ANP significantly went up. Meanwhile, the survival time was negatively correlated to the PF Amylase in the early stage (0.5 hour) of ANP (t = -9.06 InX + 129.85, r = -0.88, P < 0.01). CONCLUSIONS: The PF Amylase in the early stage of ANP can effectively predict the severity of ANP and prognosis.