三种性激素受体在原发性乳房外Paget病中的表达及意义

目的 研究探讨3种性激素受体在原发性乳房外Paget病中表达的特点及意义.方法 免疫组化法检测雄激素受体、雌激素受体和孕激素受体在30例原发性乳房外Paget病中的表达.结果 30例原发性乳房外Paget病中19例雄激素受体表达阳性.阳性率为63.3％,其中25例男性患者中阳性率为72％,5例女性患者中阳性率为20％.所有病例中雌激素受体和孕激素受体均阴性表达.结论 原发性乳房外Paget病有性激素依赖性,雄激素及其受体可能参与原发性乳房外Paget病的发生和发展.

Expressions of three sex hormone receptors in primary extramammary Paget's disease and their significance

Objective To investigate the expression profiles of three sex hormone receptors including androgen receptor (AR),estrogen receptor (ER) and progesterone receptor (PR) in primary extramammary Paget's disease (EMPD) and their significance.Methods Immunohistochemical methods were used to examine the expressions of androgen receptor,estrogen receptor and progesterone receptor in formalinfixed paraffin-embedded tissue samples from 30 patients with EMPD.Results Androgen receptor was observed in 19 (63.3％) of the 30 tissue specimens,18 (72％) of the 25 specimens from male patients,and 1 out of the 5 specimens from female patients.Neither estrogen receptor nor progesterone receptor was detected in any of these specimens.Conclusions EMPD is hormone-dependent.Androgens and their receptors may participate in the initiation and progression of primary EMPD.