前列腺素E1脂微球联合大黄治疗肝肾综合征的疗效观察

目的 观察前列腺素E1脂微球联合大黄治疗肝硬化失代偿期肝肾综合征的疗效.方法 26例肝肾综合征患者随机分为2组,在综合治疗的基础上,对照组22例患者给予多巴胺联合大剂量呋塞米,治疗组24例使用前列腺素E1脂微球联合大黄.观察两组疗效、尿量、尿素氮、肌酐、肝功能、血氨及治疗后转归情况.结果 治疗组总有效率为85.71％,...

Effect of lipoprostaglandin E1 combined with Chinese rhubarb in treating hepatorenal syndrome

Objective To observe the effect of lipoprostaglandin E1 (lipo-PegE1) with Chinese rhubarb in treatment of patients with hepatorenal syndrome.Methods 26 hepatorenal syndrome patients were divided into two groups randomly.Based on the comprehensive treatment,treatment group(24 cases)were given lipo-PegE1 with Chinese rhubarb,while control group(22 cases)were given dopamine and large-dose of furosemide.The clinical effect,total urine output,BUN,creatinine,liver function,blood ammonia and prognosis were observed.Results The total effective rate was 85.71％ in treatment group,and were significantly better than the rate(41.67％ )in control group( x2 =0.02,P ＜0.01 ).In treatment group,urine output were significantly increased after the treatment ( t =8.98,P ＜ 0.01).BUN and serum creatinine were significantly lower( t =8.53,17.22,P ＜ 0.01),ALT and TBil improved in different degree and blood ammonia decreased ( t =15.99,4.56,9.22,P ＜ 0.01 ) ; while in control group,these parameters had no significant improvement.After treatment,there were significant differences in creatinine,BUN,ALT,TBil and ammonia between the two groups( t =10.72,8.96,5.86,2.35,9.01,P ＜ 0.05).Conclusions Lipo-PegE1 can change hemodynamics and increase the urine output,while Chinese rhubarb can reduce endotoxin in patients with hepatorenal syndrome,so lipo-PegEl combine with Chinese rhubarb can get enhanced results in the treatment of hepatorenal syndrome.