| 动脉粥样硬化中巨噬细胞凋亡与内质网应激机制 |
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| 引用本文： | 崔淑华.动脉粥样硬化中巨噬细胞凋亡与内质网应激机制[J].国际病理科学与临床杂志,2011,31(4):315-318. |
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| 作者姓名： | 崔淑华 |
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| 作者单位： | 南华大学药物药理研究所,湖南衡阳,421001 |
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| 摘 要： | 巨噬细胞是机体免疫系统的重要细胞成份,具有多种生理功能,在动脉粥样硬化等血管疾病的发生和发展中具有重要作用.巨噬细胞凋亡是造成动脉粥样硬化斑块不稳定的重要因素,在晚期动脉粥样硬化中,内质网应激与巨噬细胞凋亡密切相关.目前已知的巨噬细胞凋亡途径包括外源性的死亡受体途径、内源性的线粒体途径及内质网应激凋亡途径,其中内质网应...
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| 关 键 词： | 巨噬细胞 凋亡 内质网应激 动脉粥样硬化 |
Macrophage apoptosis and the mechanisms of endoplasmic reticulum stress in atherosclerosis |
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| CUI Shuhua.Macrophage apoptosis and the mechanisms of endoplasmic reticulum stress in atherosclerosis[J].Journal of International Pathology and Clinical Medicine,2011,31(4):315-318. |
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| Authors: | CUI Shuhua |
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| Institution: | CUI Shuhua,TUO Qinhui(Institute of Pharmacy and Pharmacology,University of South China,Hengyang Hunan 421001,China) |
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| Abstract: | Macrophages are important cell component of the immune system with multiple functions and play crucial roles in the development of atherosclerosis and other vascular diseases.Macrophage apoptosis is a key factor leading to instability of atherosclerotic plaques.In the late stage of atherosclerosis,macrophage apoptosis is closely related to endoplasmic reticulum(ER) stress.Macrophage apoptosis is mediated by two central pathways: the extrinsic(or death receptor) pathway and the intrinsic(or mitochondrial,end... |
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| Keywords: | macrophage apoptosis endoplasmic reticulum stress atherosclerosis |
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