| PI3K信号通路对T细胞发育、活化、增殖、分化及支气管哮喘的作用 |
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| 引用本文： | 聂颖,李昌崇.PI3K信号通路对T细胞发育、活化、增殖、分化及支气管哮喘的作用[J].国际呼吸杂志,2011,31(19):1466-1470. |
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| 作者姓名： | 聂颖 李昌崇 |
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| 作者单位： | 325027,温州医学院附属育英儿童医院呼吸科 |
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| 基金项目： | 浙江省自然基金，浙江省大学生科技创新活动计划(新苗人才计划)资助项目 |
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| 摘 要： | T细胞是参与支气管哮喘发病的重要效应细胞,而磷脂酰肌醇-3-激酶(PI3K)是T细胞的重要信号转导分子.PI3K信号通过影响双阴性细胞的β-选择而影响T细胞的成熟,还通过激活PKB、Rac等信号途径而参与T细胞的活化、分化.同时,PI3K通过参与Th1/Th2失衡的调节,嗜酸粒细胞、肥大细胞的黏附、脱颗粒等而参与支气管...
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| 关 键 词： | PI3K信号 T细胞 发育 分化 哮喘 |
Role of PI3K signal in development, activation, differentiation of T cell and bronchial asthma |
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| NIE Ying,LI Chang-chong.Role of PI3K signal in development, activation, differentiation of T cell and bronchial asthma[J].International Journal of Respiration,2011,31(19):1466-1470. |
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| Authors: | NIE Ying LI Chang-chong |
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| Abstract: | T lymphocyte is the core cell in the bronchial asthma.The phosphoinositide3-kinase (PI3K) pathway is the important signal transduction pathway in the T lymphocyte.PI3K signaling plays a role in the development of T cells through affecting the double-negative cells of the β-selection,and T cell activation and differentiation through activation of PKB,Rac and other signaling pathway.At the same time,PI3K signal also involved in the airway inflammation of asthma including the regulation of Th1/Th2 imbalance,adhesion,degranulation of eosinophils and mast cells. |
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| Keywords: | Phosphoinositide3-kinase signal T cell Development Differentiation Asthma |
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