| 抗结核药致肝损害的研究进展 |
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| 引用本文： | 周应初,刘斌. 抗结核药致肝损害的研究进展[J]. 国际病理科学与临床杂志, 2011, 31(4): 361-365. DOI: 10.3969/j.issn.1673-2588.2011.04.018 |
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| 作者姓名： | 周应初 刘斌 |
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| 作者单位： | 中南大学湘雅二医院消化内科,长沙,410011 |
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| 摘 要： | tuberculosis药物性肝痛(drug induced hepatotoxicity,DIH)以抗结核药诱导的肝毒性(anti-tuberculosis drugs induced hepatotoxicity,ATDH)较常见,其对人体影响最大,是导致结核病人停止化学治疗最常见的原因之一.ATDH的发病机制尚不...
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| 关 键 词： | 抗结核 药物性肝痛 发病机制 危险因素 |
Reaserch progress of anti-tuberculosis drugs induced hepatotoxicity |
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| ZHOU Yingchu,LIU Bin. Reaserch progress of anti-tuberculosis drugs induced hepatotoxicity[J]. Journal of International Pathology and Clinical Medicine, 2011, 31(4): 361-365. DOI: 10.3969/j.issn.1673-2588.2011.04.018 |
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| Authors: | ZHOU Yingchu LIU Bin |
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| Affiliation: | ZHOU Yingchu,LIU Bin(Department of Gastroenterology,Second Xiangya Hospital,Central South University,Changsha 410011,China) |
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| Abstract: | Drug induced hepatotoxicity(DIH),especially the anti-tuberculosis(anti-TB) drugs induced hepatotoxicity(ATDH),impacts greatly on hunman body,and is one of the most common causes of stoping chemotherapy in tuberculosis patients.The pathogenesis of ATDH is not very clear,but the toxicity and idiosyncratic reaction have been widely studied.Its risk factors are as follows:old age,female,slow acetylation status,malnutrition,human immunodeficiency virus infection,liver diseases,excessive intake of alcohol,combina... |
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| Keywords: | anti-tuberculosis drug induced liver disease pathogenesis risk factors |
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