产肺炎克雷伯菌碳青霉烯酶肺炎克雷伯菌的研究进展

产肺炎克雷伯菌碳青霉烯酶(KPC)细菌在世界范围内广泛流行,此酶不仅见于克雷伯菌属,在诸多革兰阴性细菌中皆可检测到.产KPC细菌除了对β-内酰胺类抗菌药物耐药,对其他类抗菌药物如氟喹诺酮类、氨基糖苷类、四环素类也多表现为耐药,受到广泛关注.此文对产KPC肺炎克雷伯菌的流行病学、检测方法、感染的治疗及控制进行了综述.

Advances in Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumonia

Klebsiella pneumoniae carbapenemase (KPC)-producing bacteria is becoming increasingly prevalent worldwide.KPC are not only resticted in Klebsiella spp,but also in a variety of gram-negative bacteria.In addition to resistance to β-lactam antibiotics,KPC-producing bacteria also typically demonstrate resistance to several other classes of antibiotics,including the fluoroquinolones,aminoglycosides,and tetracyclines,so the expansive attention are given KPCproducing bacteria.The epidemiologic study,laboratory detection,treatment,prevention and control of KPC-producing Klebsiella pneumoniae are reviewed in this article.