| 内质网应激与心血管疾病 |
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| 引用本文： | 刘蜜.内质网应激与心血管疾病[J].国际病理科学与临床杂志,2011,31(4):305-309. |
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| 作者姓名： | 刘蜜 |
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| 作者单位： | 中国人民解放军总医院病理生理学研究室,北京100853;中国中医科学院西苑医院心血管病中心,北京100091 |
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| 摘 要： | 内质网应激是细胞内一种适应性机制,持续或过强的内质网应激则诱导细胞凋亡,造成组织损伤.多项研究显示内质网应激是多种心血管疾病如动脉粥样硬化、缺血性心脏病、心肌肥大、心力衰竭及糖尿痛心肌病等发生、发展的共同通路,干预内质网应激可能成为心血管疾病治疗的新靶点.
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| 关 键 词： | 内质网应激 未折叠蛋白反应 细胞凋亡 心血管疾病 |
Endoplasmic reticulum stress and cardiovascular diseases |
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| LIU Mi.Endoplasmic reticulum stress and cardiovascular diseases[J].Journal of International Pathology and Clinical Medicine,2011,31(4):305-309. |
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| Authors: | LIU Mi |
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| Institution: | LIU Mi1,2,LIU Xiuhua1 (1.Department of Pathophysiology,Chinese PLA General Hospital,Beijing 100853,2.Center for Cardiovascular Disease,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China) |
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| Abstract: | Endoplasmic reticulum(ER) stress is initially aimed at compensating for damage but can eventually trigger cell apoptosis if ER dysfunction is severe or prolonged.Plenty of evidence shows that ER stress-induced apoptosis is involved in the pathogenesis and development of many cardiovascular diseases,such as atherosclerosis,ischemic heart disease,myocardial hypertrophy,heart failure,diabetic cardiomyopathy,and so on.Therefore,intervention of ER stress may provide a potential target for treating cardiovascular... |
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| Keywords: | endoplasmic reticulum stress unfolded protein response apoptosis cardiovascular diseases |
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