| 高胰岛素血症:因还是果? |
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| 引用本文： | 杨金奎. 高胰岛素血症:因还是果?[J]. 国际内分泌代谢杂志, 2011, 31(5). DOI: 10.3760/cma.j.issn.1673-4157.2011.05.002 |
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| 作者姓名： | 杨金奎 |
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| 作者单位： | 100730,首都医科大学附属北京同仁医院内分泌科 |
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| 摘 要： | 2011年美国糖尿病协会(ADA)年会Banting科学成就奖获得者为波士顿大学的Barbara E.Corkey.她提出2型糖尿病的先决原因是高胰岛素血症,而胰岛素抵抗是其后的代偿.基础胰岛素分泌过剩的原因在于环境因素.其提出2型糖尿病的发病模型是:环境因素造成了高基础胰岛素血症.而环境因素导致胰岛素分泌过剩的共同路径是氧化还原反应的紊乱.
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| 关 键 词： | 糖尿病 高胰岛素血症 胰岛素抵抗 氧化应激 |
Hyperinsulinemia: cause or consequence |
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| YANG Jin-kui. Hyperinsulinemia: cause or consequence[J]. International JOurnal of Endocrinology and Metabolism, 2011, 31(5). DOI: 10.3760/cma.j.issn.1673-4157.2011.05.002 |
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| Authors: | YANG Jin-kui |
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| Abstract: | The Banting Lecture of American Diabetes Association (ADA) annual meeting in 2011 was delivered by Barbara E.Corkey of Boston University.She believes that the root cause of type 2 diabetes is hyperinsulinemia,and then insulin resistance as compensation.The cause of excess insulin secretion is something in the environment.Her proposed model for type 2 diabetes is:basal hyperinsulinemia caused by environmental background.Her investigations have caused her to hypothesize that the common path leading from these environmental agents to secretion of excess insulin is redox perturbations. |
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| Keywords: | Diabetes mellitus Hyperinsulinemia Insulin resistance Oxidative stress |
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