| SOCS1负性调节细胞因子和Toll样受体信号通路的研究进展 |
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| 引用本文： | 于津浦,张晶,任秀宝.SOCS1负性调节细胞因子和Toll样受体信号通路的研究进展[J].国际免疫学杂志,2011,34(6):349-352. |
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| 作者姓名： | 于津浦 张晶 任秀宝 |
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| 作者单位： | 天津市肿瘤防治重点实验室,天津医科大学附属肿瘤医院免疫室,300060 |
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| 基金项目： | 天津市自然科学基金，天津市卫生局科技基金 |
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| 摘 要： | 细胞因子(CK)信号通路和Toll样受体(TLRs)信号通路在调节免疫细胞增殖、分化和存活,以及维持免疫稳态过程中发挥重要作用.在细胞内,上述信号传导通路受多个负性调节分子的严格调控,其中细胞因子信号传导抑制蛋白1( SOCS1)是最重要的一个分子.SOCS1是一个JAK结合蛋白,可通过多靶点干预对CK和TLR信号通路...
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| 关 键 词： | 细胞因子信号传导抑制蛋白1 Toll样受体 细胞因子 信号通路 |
The mechanisms of SOCS1 mediated negative regulation of cytokine and Toll like receptors signaling pathways |
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| YU Jin-pu,ZHANG Jing,REN Xiu-bao.The mechanisms of SOCS1 mediated negative regulation of cytokine and Toll like receptors signaling pathways[J].International Journal of Immunology,2011,34(6):349-352. |
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| Authors: | YU Jin-pu ZHANG Jing REN Xiu-bao |
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| Institution: | . (Department of Immunology of Tianjin Medical University Cancer Institute ＆ Hospital, Tianfin Key Laboratory of Cancer Prevention and Therapy, Tianfin 300060, China) |
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| Abstract: | The cytokine signaling pathways and TLRs signaling pathways,play critical roles in the maintenance of immune balance and in the regulation of proliferation,differentiation,and survival of immunocytes,These are strictly signaling pathways regulated by several negative regulatory molecules,including SOCS1,SOCS1,as a JAK-binding protein,can disrupt the cytokine signaling pathways and TLRs signaling pathways by targeting multi-molecules in signal cascades and finally terminate the signal transduction.To elucidate the interactions between SOCS1 and the related signaling pathways will benefit the attempt to improve the antitumor efficiency of innate and adaptive immune systems. |
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| Keywords: | SOCS1 Toll like receptors Cytokine Signaling pathway |
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