| 呼出气冷凝液中氮氧化物在评价2型糖尿病肺损害中的作用 |
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| 引用本文： | 宋冰,李志莹,巫翠华,周燕宁,聂丽,陈立波,洪永忠,钟春,黄平.呼出气冷凝液中氮氧化物在评价2型糖尿病肺损害中的作用[J].国际呼吸杂志,2011,31(21):1618-1620. |
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| 作者姓名： | 宋冰 李志莹 巫翠华 周燕宁 聂丽 陈立波 洪永忠 钟春 黄平 |
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| 作者单位： | 1. 广东医学院附属南山医院呼吸内科,深圳,518052
2. 广东医学院附属南山医院内分泌科,深圳,518052 |
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| 摘 要： | 目的 观察2型糖尿病患者呼出气冷凝液(EBC)中氮氧化物的改变,为诊断2型糖尿病肺损害提供新方法.方法 试验共纳入36例2型糖尿病患者和31名健康者,用Rtube收集器收集EBC,用分光光度法检测EBC中氮氧化物(NO2-、NO3-、总NO2-/NO3-),同时记录肺功能.结果 2型糖尿病患者EBC中NO2-、总NO...
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| 关 键 词： | 氮氧化物 2型糖尿病 呼出气冷凝液 肺功能 |
Role of nitrogen oxides in exhaled breath condensate in pathogenesis of lung injury of type 2 diabetes |
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| SONG Bing,LI Zhi-ying,WU Cui-hua,ZHOU Yan-ning,NIE Li,CHEN Li-bo,HONG Yong-zhong,ZHONG Chun,HUANG Ping.Role of nitrogen oxides in exhaled breath condensate in pathogenesis of lung injury of type 2 diabetes[J].International Journal of Respiration,2011,31(21):1618-1620. |
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| Authors: | SONG Bing LI Zhi-ying WU Cui-hua ZHOU Yan-ning NIE Li CHEN Li-bo HONG Yong-zhong ZHONG Chun HUANG Ping |
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| Abstract: | Objective To observe the changes of nitrogen oxides in the exhaled breath condensates (EBC) of patients with type 2 diabetes,and to provide a new method for the diagnosis of lung injury in type 2 diabetes.Methods 36 patients with type 2 diabetes and 31 healthy people were recruited.The pulmonary function tests were evaluated.Nitrogen oxides in EBC were measured by the spectrophotometry and nitric oxide assay kit.Results The concentrations of NO2ˉ and NO2ˉ/NO3ˉ in EBC of type 2 diabetes patients were higher than those in healthy group (P ＜ 0.05 or P ＜ 0.01).FEV1 ％pred,DLCO and DLCO ％pred of type 2 diabetes patients were lower than those of healthy group (all P ＜0.05).The concentrations of NO2ˉand NO2ˉ/NO3ˉ in EBC of type 2 diabetes patients were relative with FEV1 ％ pred,DLCO and DLCO ％ pred ( P ＜0.05 or P ＜0.01).Conclusions Nitrogen oxides in EBC may play an important role in the pathogenesis of the lung injury of type 2 diabetes patients. |
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| Keywords: | Nitrogen oxides Type 2 diabetes Exhaled breath condansate Lung function |
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