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丁苯酞改善重度颈内动脉颅内段狭窄患者的脑血管反应性
引用本文:李敏,孙文,练学淦,刘朝来,刘新峰.丁苯酞改善重度颈内动脉颅内段狭窄患者的脑血管反应性[J].国际脑血管病杂志,2011,19(11):824-828.
作者姓名:李敏  孙文  练学淦  刘朝来  刘新峰
作者单位:1. 南京军区南京总医院神经内科, 南方医科大学临床学院,210002
2. 213003,常州市第一人民医院神经内科
基金项目:国家自然科学基金,江苏省自然科学基金
摘    要:目的 探讨丁苯酞对重度颈内动脉颅内段狭窄患者脑血管反应性(cerebrovascular reactivity,CVR)的影响.方法 将2010年1月至2010年11月期间南京卒中注册系统中经脑血管造影确诊为颈内动脉颅内段重度狭窄的患者,随机分为丁苯酞组和对照组.所有患者均给予符合指南规定的缺血性脑血管病治疗药物,丁苯...

关 键 词:3-n-丁苯酞  颈动脉狭窄  脑缺血  脑血管障碍  血管舒缩系统  超声检查  多普勒  经颅

Butylphthalide improves cerebrovascular reactivity in patients with severe intracranial internal carotid artery stenosis
LI Min,SUN Wen,LIAN Xue-gan,LIU Chao-lai,LIU Xin-feng.Butylphthalide improves cerebrovascular reactivity in patients with severe intracranial internal carotid artery stenosis[J].International Journal of Cerebrovascular Diseases,2011,19(11):824-828.
Authors:LI Min  SUN Wen  LIAN Xue-gan  LIU Chao-lai  LIU Xin-feng
Abstract:Objective To investigate the effect of butylphthalide on cerebrovascular reactivity (CVR) in patients with severe intracranial internal carotid stenosis.Methods The patients with severe intracranial internal carotid stenosis diagnosed by cerebral angiography in Nanjing Stroke Registry Program from January 2010 to November 2010 were randomly divided into either the butylphthalide group or the control group.All patients received the oral drugs for ischemic cerebrovascular disease that met the guideline criteria,and butylphthalide 20 mg,3 times a day orally was added in the butylphthalide group.The CVR was evaluated by transcranial Doppler and CO2 inhalation challenge test,and reexamined 3 months after treatment.Results A total of 81 patients met the inclusion criteria,11 (13.6%) were lost to follow-up,and finally 70 (n =35 in each group) were included in the analysis.The mean age of the patients was 55.2 ± 9.0 years,47 of them were male and 23 were female.The degree of vascular stenosis was 72% to 99% (mean 79.4% ± 9.5%).The CVR was improved significantly after 3 months of treatment in the butylphthalide group than that in the control group (P =0.007),but it was not improvedsignificantly in the control group (P =0.330).All the patients did not have ischemic stroke events during the medication.No serious adverse reactions occurred in the butylphthalide group.Conclusions Butylphthalide may improve the CVR in patients with severe intracranial internal carotid stenosis.
Keywords:3-n-Butylphthalide  Carotid stenosis  Brain ischemia  Cerebrovascular disorders  Vasomotor system  Ultrasonography  Doppler  transcranial
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