| 脂蛋白脂酶与代谢综合征 |
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| 引用本文： | 陈灶萍,刘军,查兵兵,盛励,徐炯. 脂蛋白脂酶与代谢综合征[J]. 国际内分泌代谢杂志, 2011, 31(6): 415-417. DOI: 10.3760/cma.j.issn.1673-4157.2011.06.017 |
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| 作者姓名： | 陈灶萍 刘军 查兵兵 盛励 徐炯 |
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| 作者单位： | 200240,复旦大学附属上海市第五人民医院内分泌科 |
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| 基金项目： | 上海市闵行区自然科学基金资助项目 |
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| 摘 要： | 脂蛋白脂酶是脂质代谢的关键酶,主要水解甘油三酯,在乳糜微粒及极低密度脂蛋白的代谢中发挥重要作用.该酶的缺乏或活力异常,将导致糖、脂代谢紊乱.代谢综合征(MS)是以腹型肥胖,高血压,糖、脂代谢异常等多重心血管危险因素聚集为特征的临床综合征.越来越多的动物及临床证据表明,脂蛋白脂酶参与了 MS的发生、发展,故脂蛋白脂酶的研...
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| 关 键 词： | 脂蛋白脂酶 代谢综合征 脂代谢 |
Lipoprotein lipase and metabolic syndrome |
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| CHEN Zao-ping,LIU Jun,ZHA Bing-bing,SHENG Li,XU Jiong. Lipoprotein lipase and metabolic syndrome[J]. International JOurnal of Endocrinology and Metabolism, 2011, 31(6): 415-417. DOI: 10.3760/cma.j.issn.1673-4157.2011.06.017 |
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| Authors: | CHEN Zao-ping LIU Jun ZHA Bing-bing SHENG Li XU Jiong |
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| Abstract: | Lipoprotein lipase (LPL) is the key enzyme in metabolism of lipids,which mainly hydrolyzes triglyceride (TG) and plays an important role in the metabolism of chylomicrons (CM)and very low density lipoprotein(VLDL).The defect of LPL or its abnormal activity can induce dyslipidemia and glucose metabolism disorder.Metabolic syndrome (MS) is a clinical syndrome which characterized by the cluster of cardiovascular risk factors,such as abdominal obesity,hypertension and glycolipids metabolism disorders.LPL is now considered to play an important role in the occurrence and development of MS by more and more animal and cilinical evidences,and the research of LPL will help to explore new therapeutic direction for MS. |
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| Keywords: | Lipoprotein lipase Metabolic syndrome Lipid metabolism |
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