阿托伐他汀治疗阿尔茨海默病机制探讨

目的探讨阿托伐他汀治疗阿尔茨海默病（AD）的机制。方法将50只大鼠随机分为5组，除对照组外均建立AD模型，阿托伐他汀低、中、高剂量组分别予阿托伐他汀5、10、20mg/kg药物水溶液灌胃，对照组、模型组给予等体积生理盐水灌胃，1次／d。10d后行5d水迷宫试验测试大鼠潜伏期，同时采用Western Blot法检测各组脑组织Caspase-12蛋白表达情况。结果与对照组比较，模型组潜伏期明显延长，脑组织中Caspase-12蛋白表达升高（P均〈0．05）；与模型组比较，阿托伐他汀低、中、高剂量组潜伏期明显缩短，脑组织中Caspase-12蛋白表达降低，中高剂量组更明显（P均〈0．05）。结论阿托伐他汀可改善AD大鼠学习记忆能力，机制为降低Caspase-12表达。

Study on the mechanism of atorvastatin in treating Alzheimer's disease

Objective To investigate the mechanism of atorvastatin in treating Alzheimer＇s disease （AD）. Methods 50 rats were divided into 5 groups randomly and AD model were established except the control group. The low, middle , .high dose of atorvastatin group were lavaged with atorvastatin of 5,10,20 mg/kg respectively , while the same volume saline was given to the control group and model group,once a day for 10 days. Water maze assay was applied to test rats＇ ineubation.on period for 5 days. Western-Blot were adopt to test Caspase-12 expression in brain tissue. Results Compared with the control group,the incubation period of model group postponed and the expression of Caspase-12 protein in brain tissue increased significantly （ P 〈 0.05 ）. Compared with the model group, the incubation period of low, middle and high dose of atorvastatin group shortened and the expression of Caspase-12 protein in brain tissue decreased, in particular the middlee and high dose group （ P 〈 0.05 ）. Conclusion Atorvastatin can improve the remember capability and the mechanism of it maybe down-regulate the expression of Caspase-12.