经皮雌二醇贴片与口服戊酸雌二醇在激素替代冻融胚胎移植周期临床疗效的比较

目的:比较激素替代冻融胚胎移植周期应用经皮雌二醇贴片与口服戊酸雌二醇的临床疗效。方法:回顾性队列研究分析2018年6月至2019年12月期间行激素替代冻融胚胎移植周期患者的临床资料共363例。A组患者应用经皮雌二醇贴片，B组患者口服戊酸雌二醇，比较两组患者的临床结局。结果:临床妊娠率A组为55.7%（113/203），...

Comparison of clinical efficacy of transdermal estradiol patch and oral estradiol valerate in hormone replacement frozen-thawed embryo transfer cycles

Objective To compare the clinical efficacy of transdermal estradiol patch and oral estradiol valerate in hormone replacement frozen-thawed embryo transfer cycle.Methods Clinical data of 363 patients undergoing hormone replacement frozen-thawed embryos transfer from June 2018 to December 2019 were retrospectively analyzed.Patients in group A received transdermal estradiol patch.Patients in group B received estradiol valerate orally.The clinical outcomes of the two groups were compared.Results The clinical pregnancy rate was 55.7%(113/203)in group A and 58.4%(87/149)in group B,with no significant difference between the two groups(P=0.663).There were no significant differences in human chorionic gonadotropin(hCG)positive rate[63.5%(129/203)vs.65.8%(98/149)],early abortion rate[10.6%(12/113)vs.9.2%(8/87)]and ectopic pregnancy rate[1.8%(2/113)vs.4.6%(4/87)]between the two groups(all P>0.05).The serum estradiol level in group B[(271.6±73.8)ng/L]was significantly higher than that in group A[(209.5±65.9)ng/L]on the day of endometrial conversion of progesterone(P=0.008).Conclusion The clinical effect of the transdermal estradiol patch is the same as that of oral estradiol valerate in hormone replacement frozen-thawed embryo transfer cycle.It is recommended for patients with chronic liver and kidney disease,high risk factors for thrombosis,dyslipidemia.