| Kisspeptin对下丘脑-垂体-卵巢轴的调控作用 |
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| 作者姓名： | 杨立 王青 王志 董浩旭 程玲 黄冬梅 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院中西医结合研究所;武汉市普仁医院康复中心;华中科技大学同济医学院附属同济医院中西医科;上海东方医院针灸科 |
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| 基金项目： | 国家自然科学基金(81573787);上海市浦东新区卫生系统重点学科群建设资助(PWZxq2017-13)。 |
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| 摘 要： | Kisspeptin是调节女性生殖功能重要的神经肽，主要在下丘脑促性腺激素释放激素（gonadotropin-releasing hormone， GnRH）神经元的上游起作用，与GnRH神经元上的相应受体GPR54结合后刺激GnRH的释放，从而导致生殖轴后续一系列的活动。然而，近年来研究显示，Kisspeptin不仅...
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| 关 键 词： | Kisspeptin 下丘脑 垂体 卵巢 |
Regulatory effect of Kisspeptin on hypothalamic-pituitary-ovarian axis |
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| Authors: | Yang Li Wang Qing Wang Zhi Dong Haoxu Cheng Ling Huang Dongmei |
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| Institution: | (Institute of Integrated Traditional Chinese and Western Medicine,Tongji Hospital,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Rehabilitation Center of Wuhan Puren Hospital,Affiliated Hospital of Wuhan University of Science and Technology,Wuhan 430081,China;Department of Integrated Traditional Chinese and Western Medicine,Tongji Hospital,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Acupuncture and Moxibustion,East Hospital,Shanghai 200120,China) |
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| Abstract: | Kisspeptin is an important neuropeptide regulating female reproductive function.It mainly acts on the upstream of hypothalamic gonadotropin-releasing hormone(GnRH)neurons.It binds to the corresponding receptor GPR54 on GnRH neurons to stimulate the release of GnRH,which leads to a series of subsequent activities of the reproductive axis.However,in recent years,it has been found that Kisspeptin exists not only in the central hypothalamus and pituitary,but also in the peripheral ovary,indicating that Kisspeptin not only regulates the female reproductive function in the central,but also plays a local role in the ovary.Kisspeptin is not only involved in the regulation of oocyte,granulosa cell and luteal function,but also affected by gonadotropin,photoperiod,sympathetic nerve and metabolism.This article reviews the central regulation effect and the local ovarian role of of kisspeptin. |
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| Keywords: | Kisspeptin Hypothalamus Pituitary Ovary |
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