Thyroid hormone prevents cognitive deficit in a mouse model of Alzheimer's disease |
| |
Authors: | Ai Ling Fu Cheng Yu Zhou Xiang Chen |
| |
Institution: | School of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China |
| |
Abstract: | This study aimed to examine the feasibility of using thyroid hormone (TH) as a therapeutic agent for Alzheimer's disease (AD). Mice were injected intra-hippocampally aggregated amyloid β-peptide (Aβ) to produce AD animal model. Intraperitoneal administration of l-thyroxine (L-T4) into Aβ-induced AD model mice prevented their cognitive impairment and improved their memory function. The mechanisms of L-T4 treating AD might be associated with regulating cholinergic function, protecting the brains of AD model mice against damage from free radicals, and rescuing hippocampal neurons from apoptosis. The results of the present study indicate that the use of TH has some therapeutic potential in AD. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |