Acetate metabolism and aging: An emerging connection |
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| Authors: | Tadahiro Shimazu Matthew D. Hirschey Jing-Yi Huang Linh T.Y. Ho Eric Verdin |
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| Affiliation: | 1. Department of Surgery and Medicine, Transplant International Research Centre (TIRC), Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou City, People''s Republic of China;2. Departments of Medicine, Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA;3. Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei City, People''s Republic of China;4. Department of Hemotology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA;5. Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea |
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| Abstract: | Sirtuins are NAD+-dependent protein deacetylases that regulate gene silencing, energy metabolism and aging from bacteria to mammals. SIRT3, a mammalian mitochondrial sirtuin, deacetylates acetyl-CoA synthetase (AceCS2) in the mitochondria. AceCS2 is conserved from bacteria to humans, catalyzes the conversion of acetate to acetyl-CoA and enables peripheral tissues to utilize acetate during fasting conditions. Here, we review the regulation of acetate metabolism by sirtuins, the remarkable conservation of this metabolic regulatory pathway and its emerging role in the regulation of aging and longevity. |
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