腹腔镜下胃癌根治术对患者术后恢复、免疫功能及应激状态的影响

目的:探讨腹腔镜下胃癌根治术对患者术后恢复、免疫功能及应激状态的影响。方法:选取2015年3月至2020年3月灵宝市第一人民医院普通外科一病区收治的75例行胃癌根治术的患者，男40例，女35例，年龄(57.13±6.32)岁，年龄范围为43～71岁，采用随机数表法将患者随机分为腹腔镜组( n＝37)与开腹组...

Effect of laparoscopic radical resection of gastric cancer on postoperative recovery,immune function and stress state of patients

Objective To investigate the effect of laparoscopic radical resection of gastric cancer on the postoperative recovery,immune function and stress state of patients.Methods A total of 75 patients who underwent radical resection of gastric cancer in department of General Surgery,Lingbao First People′s Hospital from March 2015 to March 2020 were selected,including 40 males and 35 females,aged(57.13±6.32)years old,ranging from 43 to 71 years old,according to the random number table method,patients were divided into the laparoscopy group(n=37)and the open group(n=38).The laparoscopy group of patients were treated with laparoscopic radical resection of gastric cancer,and the open group of patients were treated with open radical gastric cancer.The postoperative recovery(anal exhaust time,first diet time,hospital stay),immune functioncluster of differentiation 4(CD4⁺),cluster of differentiation 8(CD8⁺),CD4⁺/CD8⁺]and stress stateendothelin(ET),interleukin-6(IL-6)]were compared between the two groups.Results The postoperative anal exhaust time(2.10±1.31)days],first diet time(3.08±1.18)days]and hospitalization time(9.86±2.38)days]of the laparoscopy group were shorter than those of the open group(3.24±1.67)days,(4.12±1.35)days,(12.24±3.09)days];on the 3rd day after operation,CD4⁺(28.22±4.49)%],CD8⁺(26.18±2.67)%],CD4⁺/CD8⁺(1.08±0.10)in the laparoscopy group were high than the open group(24.01±3.69)%,(24.17±2.46)%,(1.01±0.09)];on the 3rd day after operation,the ET(0.77±0.36)ng/L]and IL-6(37.18±23.25)μg/L]of the laparoscopy group were reduced than those before operation(1.35±1.10)ng/L,(58.32±20.08)μg/L],the ET level of the open group(2.25±1.88)ng/L]was increased than that before operation(1.45±1.12)ng/L],IL-6(53.16±24.37)μg/L]was reduced than that before operation(63.45±20.42)μg/L],and ET,IL-6 in the laparoscopy group were lower than those in the open group,the difference was statistically significant(P<0.05).Conclusion.Conclusion Laparoscopic radical resection of patients with gastric cancer can shorten the postoperative recovery time and improve the immune function and stress state of the patients,which is worth of promotion.