脂肪因子CTRP1与2型糖尿病合并脑梗死患者脂代谢异常的相关性研究

目的 探讨脂肪因子CTRP1与脂肪三酰甘油脂酶(ATGL)、内皮脂肪酶(EL)和脂蛋白相关磷脂酶A2(Lp-PLA2)与2型糖尿病合并脑梗死发病的关系.方法 选取2018-12—2020-10郑州大学第二附属医院确诊的2型糖尿病患者36例、合并脑梗死患者36例及健康体检者34例为研究对象.采用酶联免疫吸附法检测血清CT...

Study on the relationship between CTRP1 and abnormal lipid metabolism in patients with type 2 diabetes mellitus complicated with cerebral infarction

Objective To investigate the role and relationship of adipokines CTRP1,adipose triglyceride lipase(ATGL),endothelial lipase(EL) and lipoprotein associated phospholipase A2(Lp-PLA2) in the pathogenesis of type 2 diabetes mellitus complicated with cerebral infarction.Methods From December 2018 to October 2020,36 patients with type 2 diabetes,36 patients with cerebral infarction and 34 healthy subjects were selected as the research objects from the Second Affiliated Hospital of Zhengzhou University.The levels of serum CTRP1,ATGL,EL and Lp-PLA2 were detected by enzyme-linked immunosorbent assay(ELISA).Combined with the relevant clinical data,the role of CTRP1 and related lipid metabolic enzymes in the occurrence of cerebral infarction in patients with type 2 diabetes mellitus were analyzed.Results TC and TG in type 2 diabetes with cerebral infarction group were significantly higher than those in control group(TC:P <0.01 and TG:P=0.047),while HDL-C was significantly lower than that in control group(P <0.037).The level of TC in patients with cerebral infarction was significantly higher than that in patients with simple diabetes mellitus(P <0.01).The level of CTRP1 in type 2 diabetes mellitus with cerebral infarction was higher than that in type2 diabetes mellitus and control group(P <0.01).The level of ATGL in the cerebral infarction group was significantly lower than that in control group and type 2 diabetes group(P=0.007,P=0.005).The levels of EL and Lp-PLA2 in cerebral infarction group were significantly higher than those in control group and diabetic group(EL:compared with diabetic group,P <0.01,compared with control group P <0.01;Lp-PLA2:compared with diabetic group,P <0.018,compared with control group,P <0.01).Serum ctrpl was positively correlated with EL and Lp-PLA2(EL:r=0.64,P<0.01;Lp-PLA2:r=0.37,P=0.026).Conclusion CTRP1 may induce/aggravate the occurrence of cerebral infarction in patients with type 2 diabetes by stimulating and regulating the levels of El and Lp-PLA2,which can be used as one of the high risk factors for cerebral infarction.