阿司匹林抵抗与大动脉粥样硬化型脑梗死复发的相关性研究

目的 探讨大动脉粥样硬化型脑梗死(LAA)复发的影响因素,并分析其与阿司匹林抵抗(AR)的相关性.方法 选取漯河市中心医院2019-01—08收治的200例大动脉粥样硬化型脑梗死患者为研究对象,根据脑梗死有无复发分为LAA未复发组(158例)和LAA复发组(42例).所有患者口服阿司匹林治疗,采用阿司匹林药物基因检测,...

Influencing factors of recurrence of large atherosclerotic cerebral infarction and its relationship with aspirin resistance

Objective To investigate the influencing factors of recurrence of large atherosclerotic cerebral infarction(LAA),and to analyze its correlation with aspirin resistance(AR).Methods Two hundred patients with large atherosclerotic cerebral infarc?tion admitted to our hospital from January 2019 to August 2019 were selected as the research objects.According to the recurrence of cerebral infarction,they were divided into LAA non-recurrence group(158 cases)and LAA recurrence group(42 cases).All pa?tients were treated with oral aspirin,and were divided into aspirin resistance group(AR group)and aspirin sensitive group(AS group)according to aspirin pharmaucogentic test.A one-year follow-up survey was conducted on the patients.Multivariate Logistic regression was used to analyze the related factors of LAA recurrence,and Spearman analysis was used to analyze the correlation be?tween LAA recurrence and AR.Results The age,the proportion of diabetes,the proportion of AR,the proportion of poor compliance with antiplatelet drugs,and the levels of TC and Hcy of patients with LAA recurrence were significantly higher than those of patients without LAA.There was a statistical difference between the two(P<0.05).Within 1 year of follow-up,among 42 patients with LAA recurrence,26 patients in the AR group(61.90%)were significantly more than 16 patients in the AS group(38.10%).There was a statistical difference between the two(P<0.05);158 patients with LAA did not relapse among the patients,25 cases(15.82%)in the AR group were significantly less than the 133 cases(84.18%)in the AS group.There was a statistical difference between the two(P<0.05).The Logistic regression equation was used to analyze the influencing factors of LAA recurrence.The patient’s age,diabetes,AR,poor compliance with antiplatelet drugs,TC,and Hcy were all independent risk factors for LAA recurrence(P<0.05).The patient’s age,diabetes,AR,and poor compliance with antiplatelet drugs were significantly positively correlated with LAA recurrence,and TC and Hcy were significantly positively correlated with LAA recurrence(P<0.05).Conclusion The factors of age,glucose and lipid me?tabolism and poor compliance of AR,antiplatelet drugs can increase the risk of recurrence in LAA patients.