滨州市中心医院抗生素的使用情况及感染病原菌和细菌耐药性的调查分析

目的:探究滨州市中心医院抗生素的使用情况及感染病原菌、细菌耐药性的调查结果。方法:滨州市中心医院检验科对2019年4月至2020年4月滨州市中心医院收治的13 982例住院患者的抗生素使用情况进行回顾性分析，男7 684例，女6 298例，年龄(40.25±8.99)岁，年龄范围为18～71岁，检测分析感染病原菌的类型...

The use of antibiotics in Binzhou Central Hospital and the investigation and analysis of infectious pathogens and bacterial resistance

Objective To investigate the use of antibiotics and infectious pathogen,bacterial resistance investigation results in Binzhou Central Hospital.Methods A retrospective study was performed on 13982 cases of patients who were admitted in department of Laboratory Medicine,Binzhou Central Hospital and given antibiotics from April 2019 to April 2020.There were 7684 males and 6298 females,aged(40.25±8.99)years old,ranging from 18 to 71 years old.The types of pathogenic bacteria,the composition of pathogenic microorganisms,and the bacterial resistance of common Gram-positive bacteria and Gram-negative bacteria were analyzed.Results Among 13982 samples,1453 positive samples were isolated,with a positive rate of 10.39%(1453/13982).A total of 1672 pathogenic microorganisms were isolated from the positive samples,including 442 strains of Gram-positive bacteria,925 strains of Gram-negative bacteria,202 strains of fungi and 103 strains of viruses.In the common Gram-positive bacteria,Staphylococcus aureus,Staphylococcus epidermidis,Enterococcus faecium and Enterococcus faecalis were significantly resistant to Azithromycin,Oxacillin,Erythromycin,Penicillin,Ciprofloxacin,Cefazolin and Levofloxacin,and the difference was statistically significant(P<0.05).There was no significant difference in resistance to Vancomycin,Chloramphenicol and Moxifloxacin(P>0.05).In the common Gram-negative,Pseudomonas aeruginosa,Klebsiella pneumoniae,Escherichia coli,Acinetobacter baumannii,Enterobacter cloacae were significantly resistant to Ampicillin,Meloxicillin,Cefoperazone,Cefotaxime,Ceftriaxone,Cefepime,Aztreonam,Ciprofloxacin and Ceftazidime(P<0.05).There was no significant difference in drug resistance to Meropenem and Amikacin(P>0.05).Conclusion The unreasonable use of antibiotics can increase the drug resistance rate of pathogenic bacteria.By conducting effective drug sensitivity tests on common pathogenic bacteria and combining with the test results,the selection of drugs with higher sensitivity can provide a reliable basis for rational clinical drug use.