| 复方山苍子油乳剂体内溶石作用及毒性的实验观察 |
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| 引用本文： | 陆才德,黄德瞻,李正之,李性定. 复方山苍子油乳剂体内溶石作用及毒性的实验观察[J]. 浙江大学学报(医学版), 1989, 0(1) |
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| 作者姓名： | 陆才德 黄德瞻 李正之 李性定 |
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| 作者单位： | 浙江医科大学附属第一医院外科，浙江医科大学附属第一医院外科，浙江医科大学附属第一医院外科，浙江医科大学附属第一医院外科 研究生 浙江医科大学附属二院外科 |
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| 摘 要： | 本实验观察复方山苍子油乳剂对植入家兔胆囊内人胆石的溶石作用药液经胆囊造瘘管注入,每日1次,每次2 ml/kg,共14次.5枚色素性结石的相对减重量为73.2±26.9%,4枚胆固醇结石的相对减重量为69.4±7.9%,明显大于对照组(P<0.01).证明复方山苍子油乳剂对植入家兔胆囊内的人胆石有肯定的溶解作用.复方山苍子油乳剂胆道灌注对家兔有一定毒性,副作用主要有腹泻和sGPT增高,应用于临床前尚需作进一步的毒理试验和配方改进.
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| 关 键 词： | 复方山苍子油乳剂 胆结石/药物作用 |
DISSOLVING EFFECT OF CUBEBA OIL CO. EMULSION IN-VIVO AND ITS TOXICITY TO RABBIT |
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| Lu Caide,Huang Deshan,Li Zhengzhi,et al.. DISSOLVING EFFECT OF CUBEBA OIL CO. EMULSION IN-VIVO AND ITS TOXICITY TO RABBIT[J]. Journal of Zhejiang University. Medical sciences, 1989, 0(1) |
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| Authors: | Lu Caide Huang Deshan Li Zhengzhi et al. |
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| Affiliation: | Lu Caide,Huang Deshan,Li Zhengzhi,et al.Division of Surgery,First Medical Faculty. |
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| Abstract: | This study investigated the dissolving effect of emulsion of cubeba oil co. infused thro tgh the cholecystostomy tube onto human gallstones, which had been previously placed into rabbits' gallbladder. The. Weight reducing rates of pigment and, cholesterol stone were 73 and 69% respectively following infusion of the emulsion for 11 times (2ml/kg, once daily).There was statistically significant difference between the experimental group and the control group(P<0.01). Emulsion of cubeba oil did dissolve human gallstones in the rabbits' gallbladder. However, toxicity in rabbit such as diarrhea and elevated sGPT was observed following infusion of emulsion of cubeba oil co. Toxicological tests and refinement of this preparation is necessory before its clinical application. |
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| Keywords: | Cubeba oil co. emulsion Cholelithiasis/drug eff |
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