递法明片对糖尿病视网膜病变暗适应功能的保护作用

目的：观察糖尿病视网膜病变( diabetic retinopathy, DR)患者行全视网膜光凝( panretinal photocoagulation, PRP)后服药前及服药2 mo 后患眼的全视野视网膜电图( full-field electroretinogram, ERG)变化,探讨递法明片对DR暗适应功能的保护作用。
　　方法：选择在我医院就诊的重度非增殖性糖尿病视网膜病变( nonproliferative diabetic retinopathy, NPDR)患者55例55眼,随机分为治疗组和对照组。两组均行全视网膜光凝,治疗组光凝后口服递法明片,对照组口服维生素B1片2次/d,10mg/次。 PRP后服药前及服药2mo后行全视野视网膜电图检查,观察其暗视视杆反应的变化并进行统计学处理。
　　结果：两组患者服药前及服药2 mo后,暗视视杆反应bT值组内及组间比较差异均无统计学意义(P>0.05)；治疗组bA值服药2 mo后与服药前相比振幅升高,差异有统计学意义(P<0.05),与对照组相比治疗组振幅升高较大,差异有统计学意义(P<0.05)。
　　结论：递法明片可减轻PRP治疗对视网膜的损害,改善患者的暗适应功能。

Study on Difrarel protecting dark adaptation function in the patients with diabetic retinopathy

AIM: To observe the change in full-field electroretinogram(ERG)in patients with nonproliferative diabetic retinopathy(NPDR)after panretinal photocoagulation(PRP)2d and 2mo, and evaluate the effects of Difrarel protecting dark adaptation function.

METHODS: Fifty-five cases with NPDR were randomly divided into the observation group and the control group.Both groups were treated with panretinal photocoagulation.Difrarel tablets was added in the observation group,and Vitamin B was added in the control group. We administered these drugs to the patients for 2mo continuously and the changes in ERG were observed after 2d and 2mo treatment. The amplitude of wave b(bA), and the peak time of wave b(bT)were observed and the data were treated statistically with SPSS 20.0 and test t in pairs.

RESULTS: The bT of the two groups before and at 2mo treatment had no difference inner group or inter-group(P>0.05). But there was obvious difference in bA of control group at 2mo after treatment compared with before treatment(P<0.05), significantly more increased amplitude of observation group than that of control group(P<0.05).

CONCLUSION: The function of each layer of PDR''s retina has been damaged obviously and cannot get well after PRP. The patients with diabetic retinopathy combined with Difrarel tablets and PRP can better restore vision and improve the dark adaptation function.