视网膜色素变性患者视盘神经纤维层厚度及视盘参数的前瞻性研究

目的：探析视网膜色素变性(RP)患者视盘神经纤维层厚度及视盘参数的研究。

方法：临床选择2015-04/2016-04本院收治的视网膜色素变性患者40例80眼为观察组，同期选择体检健康者40例80眼作为研究对照，全部研究对象进行OCT检查，比较RP患眼组与正常对照组的颞侧、上方、鼻侧、下方各象限的视网膜神经纤维层(retinal nerve fiber layer， RNFL)厚度、盘沿体积、视杯体积、杯盘垂直径比、杯盘水平直径比、杯盘面积比、盘沿面积、视杯面积、视盘面积等视盘参数。

结果：RP患眼组的全周、鼻侧、颞侧、上方、下方CP-RNFL厚度显著高于正常对照组，差异有统计学意义(P<0.05)； RP患眼组的盘沿体积、视盘体积、C/D垂直直径比、C/D水平直径比、C/D面积比、盘沿面积、视杯面积、视盘面积等视盘参数指标显著高于正常对照组，差异有统计学意义(P<0.05)。

结论：视网膜色素变性患眼的颞侧、鼻侧RNFL厚度、全周RNFL平均厚度与健康体检者相比均增厚，而其视杯体积、杯盘垂直直径比、杯盘水平直径比、杯盘面积比、视杯面积、视盘面积增大。

Study on the nerve fiber layer thickness and other parameters of optic disc in patients with retinitis pigmentosa

AIM: To study the nerve fiber layer thickness and other parameters of optic disc in patients with retinitis pigmentosa.

METHODS: Totally 40 patients(80 eyes)with retinitis pigmentosa from April 2015 to April 2016 in our hospital were selected as the observation group and 40 healthy subjects as control group. All the subjects were examined by OCT. Disc parameters of retinal nerve fiber layer(RNFL)thickness, rim volume, cup volume, cup vertical diameter ratio, cup level diameter ratio, cup area ratio, rim area, cup area, disc area in temporal, superior, nasal and inferior quadrant were compared.

RESULTS: The thickness of the whole circle, nasal, temporal, superior and inferior RNFL in the eyes of RP group was significantly higher than those in the normal control group, the difference was statistically significant(P<0.05); RP eyes group with rim volume, cup volume, cup vertical diameter ratio, cup level diameter ratio, cup area ratio, rim area, cup area, disc area parameters were significantly higher than those in normal control group, the difference was statistically significant(P<0.05).

CONCLUSION: The mean thickness of RNFL in patients with retinitis pigmentosa at temporal, nasal, the whole circle compared with healthy subjects are thicker, while cup volume, cup vertical diameter ratio, cup level diameter ratio, cup area ratio, rim area and cup area increased.