| 益气活血复方对慢性心衰大鼠血小板活化影响的实验研究 |
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| 引用本文： | 张艳,海丽,宋婷婷,庞敏,胡晓虹. 益气活血复方对慢性心衰大鼠血小板活化影响的实验研究[J]. 世界中西医结合杂志, 2008, 3(4): 198-200 |
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| 作者姓名： | 张艳 海丽 宋婷婷 庞敏 胡晓虹 |
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| 作者单位： | 辽宁中医药大学附属医院,辽宁,沈阳,110032;北京市南苑医院,北京,100076;辽宁省中医研究院,辽宁,沈阳,110034;沈空司令部705医院,辽宁,沈阳,110015 |
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| 摘 要： | 目的：研究益气活血复方对慢性心衰（CHF）大鼠血小板活化的影响。方法：以结扎冠状动脉主干下2～4mm致大鼠急性心肌梗死后，再进行饥饿及力竭式游泳造成大鼠慢性心衰模型。以彩色超声多普勒心动图测心功能。以ELISA法测定各组血栓素B2（TXB2）、降纤酶原抑制物（PAI—I）。结果：益气活血复方组可改善CHF大鼠的心脏功能；降低CHF大鼠血清中TXB2、PAI—I的含量。结论：益气活血复方有降低慢性心衰大鼠血小板活化作用．可降低心衰后血栓的发生。
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| 关 键 词： | 益气活血复方 心力衰竭 血栓素B2 降纤酶原抑制物 |
The Research of Compound Formula Yiqihuoxue on PLT Activation in Chronic Heart Failure Rats |
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| Zhang Yan,Hai Li,Song Tingting,Pang Min,Hu Xiaohong. The Research of Compound Formula Yiqihuoxue on PLT Activation in Chronic Heart Failure Rats[J]. World Journal Of Integrated Traditional and Wesrern Medicine, 2008, 3(4): 198-200 |
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| Authors: | Zhang Yan Hai Li Song Tingting Pang Min Hu Xiaohong |
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| Affiliation: | Zhang Yan, Hai Li, Song Tingting, Pang Min, Hu Xiaohong (1. The Affiliated Hospital of Liaoning University of TCM,Shenyang Liaoning 110032; 2. Beijing Nanyuan Hospital ,Bei- ring 100076;3. Traditional Chinese Medicine Institute of Liaoning Province ,Shenyang Liaoning 110034; 4. 705 Hospital of Shenyang Air Force Headquarters, Shenyang Liaoning 110015) |
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| Abstract: | Objective：To study compound formula Yiqihuoxue effect on PLT activation of chronic heart failure（CHF）rats. Methods：To ligate the part 2-4 mm inferior to main coronary artery to cause myocardial infarction in rats. CHF were further induced by starvation and exhaustedly-swim. Cardiac function was determined by color Doppler echoeardiography and TXB2 and PAl- I by ELISA. Results：Compound formula Yiqihuoxue improved the cardiac function and reduced TXB2, PAI- I in serum of CHF rats. Conclusion：Compound formula Yiqihuoxue can depress the PLT activation on CHF rats and may block thrombus formation after CHF. |
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| Keywords: | Compound formula Yiqihuoxue chronic heart failure TXB2 PAI- I |
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