原发性高血压患者血压变异性与肾功能损害的相关性研究

目的：观察原发性高血压患者血压变异性对肾功能损害的影响。方法：对86例轻中度原发性高血压患者按24h收缩压血压变异性均值递增顺序分为EH1组（43例）和EH2组（43例）。进行24h动态血压监测和24h尿微量清蛋白及肾功能生化测定,观察并比较患者血压变异性对肾功能损伤的影响。结果：两组患者血压变异性有非常显著性差异（P〈0.01）;24h、日间、夜间收缩压和舒张压的血压平均值比较无显著性差异（P〉0.05）;24h尿微量清蛋白有非常显著性差异（P〈0.01）。除了日间收缩压血压变异性与尿蛋白无明显相关性外,其余时间收缩压和舒张压血压变异性与尿蛋白的分泌均呈正相关。EH1组与EH2组血肌酐、血尿素氮比较无显著性差异（P〉0.05）。结论：原发性高血压患者血压变异性与高血压性肾脏损伤密切相关。

The relevant research between hypertension variability and renal dysfunction in primary high blood pressure patients

Objective：To evaluate the association between blood pressure variability and renal function injury in the patients with essential hypertension. Methods：86 cases of patients with mild to moderate essential hypertension were divided into EH1 group （43 cases） and EH2 group （43 cases） based on the mean variability of 24 h systolic blood pressure in ascending order. 24 h ambulatory blood pressure,quantitative of 24 h urine microalbumin and renal function determination were recorded. Results：The blood pressure variability of two groups has a significant difference （P〈0.01）,mean SBP and DBP of 24 h,daytime,night-time were no statistical significance （P〉0.05）,the quantitative of 24 h urine microalbumin of two groups were significant difference （P〈0.01）,the SBP and DBP blood pressure variability were positive correlation with 24 h urine microalbumin except the daytime blood pressure variability. Serum creatine （Scr） and serum BUN of two groups were no significant difference（P〉0.05）. Conclusion：Blood pressure variability is closely related with hypertensive renal injury in the patients with essential hypertension.