巨噬细胞移动抑制因子对固有免疫的调节作用 |
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引用本文: | 奚正德,胡峻熊. 巨噬细胞移动抑制因子对固有免疫的调节作用[J]. 国际免疫学杂志, 2008, 31(3) |
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作者姓名: | 奚正德 胡峻熊 |
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作者单位: | 1. 上海市免疫学研究所,上海交通大学医学院,200025 2. 上海联合赛尔生物工程有限公司,201206 |
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摘 要: | 长期以来,巨噬细胞移动抑制因子(MIF)一直是一种功能不明的细胞因子.最近几年的研究发现,MIF是宿主抗微生物预警系统和应急反应(可以促进免疫细胞促炎症功能)的一个必要组成成份,是一种对固有免疫反应具有关键性调节作用的重要分子.研究表明,MIF参与了包括脓毒症、炎症和自身免疫性炎症疾病在内的一系列疾病的发病机制,这为未来使用靶向MIF疗法治疗相关的人类疾病提供了全新的思路.
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关 键 词: | 巨噬细胞移动抑制因子 固有免疫 脓毒症 炎症 自身免疫性炎症疾病 |
Critical role of macrophage migration inhibitory factor in innate immunity regulation |
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Abstract: | For more than three decades, macrophage migration inhibitory factor (MIF) has been a mysteri-ous cytokine with unknown function. Researches in recent years found that MIF is an essential component ofthe host antimicrobial alarm system and stress response which can promote the pro-inflammatory functions ofimmune cells, and it is a crictical molecule playing a role in regulating innate immune response. Recent evi-dences show that MIF is involved in the pathogenesis of sepsis, inflammation , and auotoimmune inflammato-ry diseases, and offer novel strategy to treat these diseases by targetting MIF. |
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Keywords: | Macrophage migration inhibitory factor Innate immunity Sepsis Inflammation Autoimmuneinflammatory disease |
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