神经肽Y促进肥胖的研究进展

 神经肽Y(neuropeptide Y,NPY)是重要的促肥胖因子,广泛分布于中枢和外围神经系统,因此成为研发减肥药物的重要靶点。既往研究主要集中于NPY的中枢促摄食作用,但越来越多的证据表明NPY对能量代谢的调节是从多方面进行的。中枢和外围NPY均能通过促进棕色脂肪组织(brown adipose tissue,BAT)堆积而导致肥胖,本文主要从中枢和外周两方面对NPY的分布及其在肥胖发生发展过程中的作用进行综述。

Advances in neuropeptide Y (NPY) promoting obesity

Neuropeptide Y (neuropeptide Y,NPY) is an important factor that promotes obesity that widely distributes in central and perpheral nervous system,thus making it a target for the development of drugs to lose weight.Although most researches have been focusing on its role in stimulating appetite,more and more evidence demonstrated that NPY regulates energy metabolism in many ways.Central and peripheral NPY can promote the storage of brown adipose tissue (BAT),which finally lead to obesity.This review summarizes distributions of NPY and its role in the development of obesity both centrally and peripherally.