| 联合N端脑钠肽前体、估算的肾小球滤过率及超敏C-反应蛋白对急性心肌梗死患者院内发生1型心肾综合征的危险分层评估 |
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| 引用本文： | 张德强,李虹伟,陈海平,马清,陈晖,刑云利.联合N端脑钠肽前体、估算的肾小球滤过率及超敏C-反应蛋白对急性心肌梗死患者院内发生1型心肾综合征的危险分层评估[J].中华老年多器官疾病杂志,2019,18(4):261-265. |
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| 作者姓名： | 张德强 李虹伟 陈海平 马清 陈晖 刑云利 |
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| 作者单位： | 首都医科大学附属北京友谊医院医疗保健中心内科,北京 100050,首都医科大学附属北京友谊医院医疗保健中心内科,北京 100050,首都医科大学附属北京友谊医院医疗保健中心内科,北京 100050,首都医科大学附属北京友谊医院医疗保健中心内科,北京 100050,首都医科大学附属北京友谊医院医疗保健中心内科,北京 100050,首都医科大学附属北京友谊医院医疗保健中心内科,北京 100050 |
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| 摘 要： | 目的观察N端脑钠肽前体(NT-proBNP)、估算的肾小球滤过率(eGFR)及超敏C-反应蛋白(hs-CRP)对急性心肌梗死患者在院内发生1型心肾综合征(CRS1)及危险分层中的作用。方法回顾性分析2012年12月至2017年2月北京友谊医院心血管中心数据库中急性心肌梗死患者2 094例。收集包括NT-proBNP、eGFR及hs-CRP在内的临床资料。按照每组人数大致相等的原则,分段考察NT-proBNP、eGFR及hs-CRP的值与CRS1发生率和院内死亡率之间的关系。采用SPSS 22.0统计软件进行统计学分析。Kaplan-Meier生存分析及COX比例风险回归评估异常指标的数目对院内死亡的影响。结果随着NT-proBNP的升高、eGFR的下降以及hs-CRP的升高,急性心肌梗死患者的院内CRS1发生率及院内死亡率均有升高趋势(P0.05)。随着CRS1加重,eGFR有下降趋势,NT-proBNP及hs-CRP在CRS1达到重度之前具有升高趋势。Kaplan-Meier生存分析显示,患者的院内累积生存率随着异常指标数目的增加而降低(P0.001)。≥2个指标异常是患者院内死亡的独立危险因素(RR=2.452,95%CI 1.105～5.440;P=0.027)。结论联合NT-proBNP、eGFR和hs-CRP将有助于对急性心肌梗死患者院内发生CRS1进行危险分层。
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| 关 键 词： | 肾小球滤过率 1型心肾综合征 N端脑钠肽前体 超敏C-反应蛋白 危险分层 |
| 收稿时间： | 2019/2/12 0:00:00 |
Stratified risk analysis for in-hospital development of type 1 cardio-renal syndrome in patients with acute myocardial infarction using a combination of N-terminal pro-brain natriuretic peptide, estimated glomerular filtration rate and high sensitivity C-reactive protein |
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| ZHANG De-Qiang,LI Hong-Wei,CHEN Hai-Ping,MA Qing,CHEN Hui and XING Yun-Li.Stratified risk analysis for in-hospital development of type 1 cardio-renal syndrome in patients with acute myocardial infarction using a combination of N-terminal pro-brain natriuretic peptide, estimated glomerular filtration rate and high sensitivity C-reactive protein[J].Chinrse journal of Multiple Organ Diseases in the Elderly,2019,18(4):261-265. |
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| Authors: | ZHANG De-Qiang LI Hong-Wei CHEN Hai-Ping MA Qing CHEN Hui and XING Yun-Li |
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| Institution: | Internal Medical Department, Medical Health Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China,Internal Medical Department, Medical Health Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China,Internal Medical Department, Medical Health Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China,Internal Medical Department, Medical Health Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China,Internal Medical Department, Medical Health Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China and Internal Medical Department, Medical Health Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China |
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| Abstract: | |
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| Keywords: | glomerular filtration rate type 1 cardiorenal syndrome N-terminal pro-brain natriuretic peptide high sensitivity C-reactive protein risk stratification |
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