| 自噬调控衰老的研究进展 |
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| 引用本文： | 牟婕,冯文静,王珊,冯美苹,毛拥军. 自噬调控衰老的研究进展[J]. 中华老年多器官疾病杂志, 2019, 18(1): 60-63 |
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| 作者姓名： | 牟婕 冯文静 王珊 冯美苹 毛拥军 |
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| 作者单位： | 青岛大学附属医院老年医学科,青岛 266000,青岛大学附属医院老年医学科,青岛 266000,青岛大学附属医院老年医学科,青岛 266000,青岛大学附属医院老年医学科,青岛 266000,青岛大学附属医院老年医学科,青岛 266000 |
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| 基金项目： | 国家自然科学基金(31571829；31640050)；山东省自然科学基金(ZR2016HR23) |
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| 摘 要： | 随着机体老化,组织器官可发生不可逆退行性改变,这些变化与疾病和死亡密切相关。自噬是细胞内一种重要的分解代谢过程,在维持细胞稳态和促进长寿中起重要作用,机体衰老后,其自噬调节能力也随之下降。本文综述了自噬与衰老相关疾病的关系,明确自噬调控衰老的相关分子机制可能为治疗衰老相关疾病提供新的靶点。
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| 关 键 词： | 自噬 衰老 基因表达调控 |
| 收稿时间： | 2018-07-17 |
| 修稿时间： | 2018-08-21 |
Research progress of regulation of the aging process by autophagy |
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| MOU Jie,FENG Wen-Jing,WANG Shan,FENG Mei-Ping and MAO Yong-Jun. Research progress of regulation of the aging process by autophagy[J]. Chinese Journal of Multiple Organ Diseases in the Elderly, 2019, 18(1): 60-63 |
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| Authors: | MOU Jie FENG Wen-Jing WANG Shan FENG Mei-Ping MAO Yong-Jun |
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| Affiliation: | Department of Geriatrics, the Affiliated Hospital of Qingdao University, Qingdao 266000, China,Department of Geriatrics, the Affiliated Hospital of Qingdao University, Qingdao 266000, China,Department of Geriatrics, the Affiliated Hospital of Qingdao University, Qingdao 266000, China,Department of Geriatrics, the Affiliated Hospital of Qingdao University, Qingdao 266000, China and Department of Geriatrics, the Affiliated Hospital of Qingdao University, Qingdao 266000, China |
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| Abstract: | Irreversible degenerative changes occur in tissues and organs as the body ages, and these changes are closely associated with disease and death. Autophagy, an important catabolic process in cells, plays a significant role in maintaining cell homeostasis and promoting longevity. Regulatory capacity of autophagy declines after aging. In this paper, we reviewed the relationship between autophagy and aging-associated diseases, claiming that the molecular mechanism of regulation of the aging process by autophagy may provide a new target for the treatment of aging-associated diseases. |
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| Keywords: | autophagy aging gene expression regulation |
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