骨钙素(OCN)与非酒精性脂肪肝(NAFLD)关系的研究进展

 骨钙素(osteocalcin,OCN)是由成骨细胞生成并特异性分泌的非胶原蛋白,参与调节胰岛素分泌、葡萄糖代谢和能量消耗,成为骨和调节能量代谢器官的复杂信号通路之间的重要话串的关键分子。肝脏作为代谢中枢器官参与多种物质代谢。动物及细胞分子学实验显示,OCN具有改善肝脏脂肪过量沉积的作用,其机制可能与OCN降低血清三酰甘油水平、促进胰岛素分泌、改善胰岛素抵抗、减轻氧化应激及炎性反应等相关。多项临床研究表明,OCN与糖代谢、脂代谢、肥胖等代谢异常密切相关,但OCN与非酒精性脂肪肝病(non alcoholic fatty liver disease,NAFLD)的关系研究目前仍存在争议。

Research progress in the association of osteocalcin (OCN) and non-alcoholic fatty liver disease (NAFLD)

Osteocalcin (OCN),an osteoblast-specific secretory non-collagenous protein,is involved in the regulation of insulin secretion,glucose metabolism and energy consumptions as one of the key moleculars in the important crosstalk between skeleton system and energy metabolic organs.As the central organ of energy metabolism,the liver participates in multiple metabolic pathways.Fundamental studies demonstrated that hepatic steatosis could be rescued by OCN.The possible mechanism may be associated with the decreased serum triglyceride level,increased insulin secretion,improved insulin sensitivity,reduced oxidative stress and inflammatory reactions.Furthermore,mounting clinical studies showed that OCN was closely related to glucose metabolism,lipid metabolism and obesity,but the relationship between OCN and non alcoholic fatty liver disease (NAFLD) remains controversial.