泌尿生殖道支原体感染及耐药性

目的探讨泌尿生殖道支原体感染的现状及耐药性,为临床医师合理用药提供依据。方法应用法国Bio-Merieux生产的IST试剂盒进行支原体培养及药敏试验,并分析结果。结果312例疑似非淋菌性尿道炎(NGU)患者中,128例支原体培养阳性,阳性率为41.0%;其中,解脲脲支原体(Uu)占71.9%;人支原体(Mh)占2.3%;Uu Mh阳性者占25.8%;药敏结果表明:支原体对9种抗菌药物耐药率最高的是红霉素(58.7%)、环丙沙星(50.0%)、氧氟沙星(41.3%);耐药率较低的药物为普那霉素(3.3%)、交沙霉素(5.4%)、多西环素(7.6%)。结论泌尿生殖道支原体感染主要以Uu发病率最高,对支原体感染治疗应根据药敏结果合理使用抗生素,目前可首选交沙霉素进行治疗。

Infection Status and Drug-susceptibility Analysis of Mycoplasma Strains Isolated from Genitourinary Tract

OBJECTIVE To investigate the infection status and drug resistance of Mycoplasma strains isolated from genitourinary tract. METHODS The IST kit produced by Bio-Merieux was used to culture the Mycoplasma strains and to do drug susceptibility test. RESULTS The Mycoplasma infection ratio was 41.0%,with Ureaplasma urealyticum(Uu) 71.9%,Mycoplasma hominis(Mh) 2.3%,and mixed infection 25.8%,respectively.The drug susceptibility test showed that drug resistance ratios were as follows: to erythromycin 58.7%,ciprofloxacin 50.0%,ofloxacin 41.3%,pristinamycin 3.3%,josamycin 5.4% and doxycycline 7.6%. CONCLUSIONS Mycoplasma infection in genitourinary tract is mainly due to Uu infection.We should rationally choose and use antibiotics according to the drug susceptibility,and josamycin is very effective.