人红细胞抗氧化蛋白和抗氧化酶在间歇性低氧暴露后的变化

目的 :观察人体血液中红细胞抗氧化蛋白 (HRPRP)、SOD酶、GSH -PX酶在间歇性低氧暴露后的变化 ,观察抗氧化系统在间歇性低氧暴露后的反应是否有利于运动能力的提高。方法 :男性大学生 1 5名随机分成对照组和实验组 ,两组从事相同身体活动 ,实验组每天安静状态下间歇吸低氧 (浓度 1 4 %～ 1 0 %) 5 0～ 6 0分钟 ,连续 4周。两组均在实验开始前、结束后按Bruce方案进行力竭运动 ,并在安静和运动后取血测试HRPRP、SOD、GSH -PX、MDA。结果 :间歇性低氧暴露后 ,HRPRP含量和红细胞抗氧化酶SOD、GSH -PX活性在安静时和力竭运动后明显提高 ,运动时间延长 ,最大吸氧量增加。结论 :间歇性低氧暴露有助于增强红细胞抗氧化能力 ,改善和提高运动能力。

Change of HRPRP and Antioxidant Enzymes after Intermittent Hypoxia Exposure

Objective This paper investigated the effects of intermittent hypoxia exposure (IHE) on HRPRP?SOD?GSH-PX?MDA and exercise performance. Methods Fifteen male students were randomly assigned to group of control and IHE. The IHE group intermittently inhaled different hypoxic gas mixtures (O 2% were 14%, 12%, 10%, respectively),50～60 mins daily for 4 weeks. Both groups completed Bruce protocol exercise on the treadmill before and after IHE. The HRPRP, SOD, GSH-PX, MDA were measured at rest and post exercise respectively. Results The concentration of HRPRP and the activity of SOD, GSH-PX were increased as well as VO 2max and the time to exhaustion. Conclusion IHT is effective on improving the antioxidant capacity and sports performance.