Comparison between bacillus Calmette-Guérin and the A60 mycobacterial antigen complex used as cancer-preventive immunotherapies |
| |
Authors: | Hubert Maes Henryk Taper Carlo Cocito |
| |
Affiliation: | (1) Microbiology and Genetics Unit, Medical School, Catholic University of Louvain GEMO 5225, Tour Vésale, Ave. Mounier 52, B-1200 Brussels, Belgium;(2) Toxicological and Cancerological Biochemistry Unit, School of Pharmacy, Catholic University of Louvain, 1200 Brussels, Belgium |
| |
Abstract: | Preparations of live or lysates ofMycobacterium bovis strain Calmette-Guérin (BCG) have long been used as treatments for a variety of cancer types, especially those involving the urinary tract, with varying success. This study was conducted to compare the antitumoral activity of BCG and the thermostable macromolecular antigen complex of BCG (A60) when used as preventive treatments, in conjunction with or without tumor antigens, against growth and dissemination of the EMT6 murine tumor cell line. It was demonstrated that tumor antigens alone did not significantly alter the oncological indexes, although a slight increase in both T lymphocyte and macrophage activations was found. It was further demonstrated that A60 induces a protective activity up to 40% greater than that of live BCG and that this protection was not accompanied by any of the adverse effects sometimes observed during BCG immunotherapy.Abbreviations BCGMycobacterium bovis strain Calmette-Guérin - A60 the thermostable macromolecular antigen complex ofM. bovis BCG - EMT6 murine transplantable mammary adenocarcinoma - ELISA enzyme-linked immunosorbent assay |
| |
Keywords: | BCG Antigen A60 Cancer-preventive immunotherapy EMT6 |
本文献已被 SpringerLink 等数据库收录! |
|