颅骨与腰椎骨髓转化的MR定量研究及临床应用

目的 :从定量角度探讨MRI上颅骨与腰椎骨髓转化特点并评估骨髓相对信号强度 (RSI)的诊断价值。方法 :正常组 2 5 7例 ,其中颅骨 10 1例 ,腰椎 15 6例 ;异常组 6例 ,白血病 5例 ,多发性骨髓瘤 1例。MR扫描仪为 0 .5TPhilipsGyroscan。成像序列为TSET1 WI ,测定颅骨和腰椎骨髓的RSI并进行F检验、相关分析及动态分析。结果 :腰椎和颅骨骨髓RSI与年龄呈明显正相关 (P <0 .0 1)。颅骨骨髓RSI的净增量及平均增长速度大于腰椎。正常组颅骨骨髓与腰椎骨髓RSI在不同年龄段之间差异有显著性意义。异常组骨髓RSI值明显低于相应年龄段正常均值。结论 :骨髓RSI在不同年龄段间存在显著性差异 ,颅骨骨髓转化程度、速度均较腰椎显著。RSI对弥漫性骨髓浸润性疾病有较高的敏感性 ,但缺乏特异性。

MR quantitative measurement of the bone marrow conversion of cranial bone and lumbar spine

Objective: To discuss MR characteristics of marrow conversion of cranial bone and lumbar spine and to assess the diagnostic value of relative signal intensity (RSI) in some bone marrow diseases.Methods:257 cases of normal bone marrow and 7 patients with bone marrow diseases were studied. The normal bone marrow included 101 cranial bones and 156 lumbar spines. The bone marrow diseases included multiple myeloma (n=2) and leukemia (n=5). The scanner used was 0.5T Philips Gyroscan and imaging sequence employed was TSE T1WI.The RSI of bone marrow measured was statistically analyzed.Results:The net increased value and average increased rate of RSI of bone marrow in basiocciptal bone were higher than those of lumbar spine. RSI of the basiocciptal bone and lumbar spine was significantly different among different ages.The RSI value of hematologic diseases was lower than that of normal cases.Conclusion:Bone marrow RSI has significant difference in different ages.The conversion degree and speed of the cranial bone are more obvious than that of lumbar spine.In addition,RSI has high sensitivity but lower specificity in diffusive bone marrow diseases.