| 用中效原理分析维生素K2与顺铂对人肺癌SPC-A-1细胞株的协同作用 |
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| 引用本文： | 耿建,陈龙邦,鹿红,臧静.用中效原理分析维生素K2与顺铂对人肺癌SPC-A-1细胞株的协同作用[J].医学研究生学报,2006,19(5):391-393. |
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| 作者姓名： | 耿建 陈龙邦 鹿红 臧静 |
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| 作者单位： | 南京大学医学院临床学院(南京军区南京总医院),肿瘤内科,江苏,南京,210002 |
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| 摘 要： | 目的：研究维生素K2对人肺癌SPC-A-1细胞株的细胞毒作用及其与顺铂（Cisplatin）联合应用的相互作用.方法：MTT比色法观察维生素K2单独及与顺铂联合应用在体外对肺癌SPC-A-1细胞株的抑制作用,利用中效方程分析两药协同效应.结果：维生素K2与顺铂单用及合用时随着药物浓度增加其效应肿瘤抑制率（fa）也增加,两药合用时的中效浓度小于两药单用时的中效浓度之和,且两药无排斥性.随着维生素K2浓度的增加,其fa逐渐降低,合用指数（CI）逐渐降低,当与浓度为0.01μg/ml的顺铂联合应用,维生素K2浓度＞18.57μg/ml时,两药即可产生协同作用.结论：维生素K2与顺铂联合应用优于单药对SPC-A-1细胞株的抑制作用.
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| 关 键 词： | 维生素K2 顺铂 肺癌SPC-A-1细胞株 |
| 文章编号： | 1008-8199(2006)05-0391-03 |
| 修稿时间： | 2005年9月9日 |
Synergetic cytotoxicity of vitamin K2 and cisplatin on human lung adenocarcinoma cell line SPC-A-1 |
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| GENG Jian,CHEN Long-bang,LU Hong,ZANG Jing.Synergetic cytotoxicity of vitamin K2 and cisplatin on human lung adenocarcinoma cell line SPC-A-1[J].Bulletin of Medical Postgraduate,2006,19(5):391-393. |
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| Authors: | GENG Jian CHEN Long-bang LU Hong ZANG Jing |
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| Abstract: | Objective:To investigate the suppressive effects of vitamin K2 on human adenocarcinoma cell line SPC-A-1 and the interaction between vitamin K2 and cisplatin. Methods:The cytotoxic indexes of vitamin K2 alone or combined with cisplatin on SPC-A-1 cells were detected by MTT method. Results:SPC-A-1 was sensitive to vitamin K2 with a positive correlation between cytotoxic index and vitamin K2 concentration. There were significant synergetic effects in cytotoxicity of vitamin K2 combined with cisplatin on SPC-A-1 cells. Conclusion:Vitamin K2 is a promising agent in the treatment of human lung cancer. |
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| Keywords: | Vitamin K2 Cisplatin Lung adenocarcinoma cell line |
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