腺泡状软组织肉瘤临床病理研究及文献复习

目的探讨腺泡状软组织肉瘤(ASPS)的临床病理特征、诊断及鉴别诊断。方法对1例ASPS进行HE染色,光镜观察,并进行组织化学及免疫组织化学染色,结合文献综合讨论。结果1例ASPS为23岁女性,病变位于左臀部深部骨骼肌组织内,大体上为有包膜境界清楚的肿块。光镜下肿瘤细胞呈腺泡状或巢状排列,周围为富含血窦的间质。瘤细胞呈圆形或多边形,胞浆丰富,内含丰富的嗜酸性颗粒及结晶体。核仁明显,核分裂像少见。PAS染色强阳性。免疫组化染色:Myoglob in( )、Myosin、Desm in、SMA、V im entin、S-100、EMA和Syn均为(-)。结论ASPS为一种少见的软组织恶性肿瘤,其组织起源不明,确诊必须依靠病理检查,治疗以手术为主。

Clinicopathologic study and review of alveolar soft part sarcoma

Objective To investigate the clinicopathologic features and differential diagnosis of alveolar soft part sarcoma(ASPS).Methods A case of ASPS was studied by HE stain,light microscopic observation,histochemical stain and immunohistochemical stain,and discussed the disease synthetically with the literature.Results The patient was female,23 years old.The lesion was located in the deep skeletal muscles of left buttocks,microscopically,which consisted of round to polygonal tumor cells,showing alveolus and nest arrangement,arounded by stroma containing sinusoidal capillaries,and there were abundant crystals in cytoplasm of the tumor cells,prominent nucleoli and fewer nuclear fission images in the tumor cells.PAS stain was stongly positive.Immunohistochemical stain showed positive expression of myoglobin in tumor cells,and negative expression of Myosin,Desmin,SMA,Vimentin,S-100 protein,EMA and Syn in them.Conclusion ASPS is a rare malignant soft tissue neoplasm,its histogenesis is uncertain,and diagnosed by pathological examine and treated mainly by operation.