Study on the Effects of L-5HTP on the Stages of Sleep in Man as Evaluated by Using Sleep Deprivation |
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| Authors: | Yoichi Nakazawa M.D Hiroaki Hasuzawa M.D Tatayu Kotorii M.D Toshihiko Ohkawa M.D Hiroshi Sakurada M.D Kensaku Nonaka M.D Keijiro Dainoson M.D |
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| Affiliation: | Department of Neuropsychiatry, School of Medicine, Kurume University, Kurume |
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| Abstract: | Abstract: The effects of L-5HTP 200 mg on the EEG sleep pattern were investigated in normal subjects. When L-5HTP 200 mg was orally administered, only %S1 significantly decreased in comparison with the baseline. There was no change in any sleep stage on the first recovery night. On the second recovery night, %S1 significantly decreased, while %SR increased significantly. SWS did not show any change. The effects of L-5HTP 200 mg were investigated on the first recovery night after one night of sleep deprivation. SWS significantly increased on the first recovery night when a placebo was given, while this rebound increase of SWS disappeared and %S2 significantly increased on the first recovery night when L-5HTP was given. %SR significantly increased on the next night after the L-5HTP night. |
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| Keywords: | human sleep L-5HTP slow wave sleep REM sleep sleep deprivation |
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