乳腺癌中血管内皮生长因子和抑癌基因p33ING1的表达及意义

目的观察血管内皮生长因子(VEGF)和抑癌基因p33ING1蛋白在乳腺癌组织中的表达及意义。方法采用免疫组织化学法检测90例乳腺癌组织和癌周正常组织中VEGF和p33ING1的表达水平。结果VEGF在正常乳腺组织中表达率为44.4%,在乳腺癌组织中的表达率为91.1%,两者差异有统计学意义(P<0.01),p33ING1在正常乳腺组织中表达率为94.4%,在乳腺癌组织中的表达率为63.3%,两者差异有统计学意义(P<0.01)。VEGF蛋白表达水平与乳腺癌TNM分期、淋巴结转移有关(P<0.01),p33ING1蛋白表达水平与乳腺癌肿瘤大小、TNM分期、淋巴结转移有关(P<0.05)。结论VEGF与p33ING1的表达与乳腺癌发展有关,进行VEGF与p33ING1免疫组织化学法检测对判断乳腺癌生物学行为和预后具有参考价值。

Expression of vascular endothelial growth factor and p33ING1 in breast carcinoma and significance

Objective To study the expression of vascular endothelial growth factor(VEGF)and p33ING1 in breast carcinoma,and their relation to the clinicopathological features.Methods VEGF pro- tein and p33ING1 protein expression in 90 cases of human breast carcinoma tissues and normal tissues a- round the foci was detected by using immunohistochemical method.Results The overexpression rate of VEGF protein was 91.1% in breast carcinoma tissues,and 44.4% in normal tissues(P<0.01 ),while the overexpression rate of p33ING1 protein was 63.3% in breast carcinoma tissues,and 94.4% in normal tissues(P<0.01 ).The expression of VEGF was related to TNM stage and lymph node metastasis(P<0.01),and there was a close relationship between the expression of p33ING1 and tumor size,TNM stage and lymph node metastasis(P<0.05).Conclusion VEGF and p33ING are positively correlated with development of breast carcinoma,suggesting that detection of VEGF and p33ING1 may be of value in cal- culating the biological behaviors and the prognosis of breast carcinoma.