62例肌萎缩侧索硬化的临床分析

目的探讨肌萎缩侧索硬化（Amyotrophic Lateral Sclerosis，ALS）的临床和电生理特征。方法收集2004年1月1日至2010年6月30日期间佛山市中医院神经内科收治的62例ALs患者，回顾性分析这些病人的资料并总结其I临床特征。结果本组病人的主要临床特征为慢性隐袭起病，中老年发病（平均发病年龄为49．3岁），男性多发（男女比例为1．48：1）．首发症状多为羊侧上肢肌无力（54．8％），可伴有肌肉萎缩，吞咽、言语困难等，电生理检查均表现为脑神经和多个脊髓节段广泛的神经源性损害。结论肌萎缩侧索硬化症是一种累及脊髓前角细胞、脑干运动神经核及锥体柬，具有上Tig动神经元损害并存的慢性进行性神经系统变性疾病。早期诊断是本病的难点，且容易出现误诊。肌电图对本病的诊断和鉴别诊断有重要意义。

Clinical Analysis of 62 Cases of Amyotrophic Lateral Sclerosis

Objective To study the clinical features and EMG changes of amyotrophic lateral sclerosis (ALS).Methods We collected and reviewed prospectively the clinical records of 62 cases of ALS,and tried to find their features.Results The cases in the study were characterized by insidious onset,ingravescence,middle-aged commonness (the average age at onset was 49.3 years) and male predominance (the ratio of male vs.female was 1.48 : 1).It was more frequent that the first symptom of ALS was the weakness of single uppe...