| 川芎嗪对肺纤维化大鼠CTGF表达及胶原沉积的影响 |
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| 引用本文： | 江茵,李文,陈敏.川芎嗪对肺纤维化大鼠CTGF表达及胶原沉积的影响[J].实用全科医学,2008,6(12):1215-1216. |
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| 作者姓名： | 江茵 李文 陈敏 |
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| 作者单位： | [1]广东省广东医学院诊断学与内科学教研室,524001 [2]广东省广东医学院附属医院呼吸疾病研究所,524001 |
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| 摘 要： | 目的通过观察川芎嗪对肺纤维化大鼠肺内结缔组织生长因子（Connective tissue growth factor，CTGF）表达及胶原沉积的影响，探讨川芎嗪对肺纤维化的治疗作用。方法将72只雄性SD大鼠随机分为正常对照组（A组）、肺纤维化模型组（B组）、川芎嗪治疗组（C组）各24只，采用大鼠气管内一次性滴注博莱霉素造模，Masson染色观察胶原沉积情况及SABC免疫组化法检测CTGF表达变化。结果B组肺内有大量胶原沉积；C组胶原沉积明显轻于B组；A组胶原沉积不明显。免疫组化发现B组CTGF表达最强，C组较弱，A组微弱表达。结论川芎嗪可抑制哮喘大鼠肺组织的胶原沉积。其作用机制可能是通过抑制CTGF的表达来实现。
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| 关 键 词： | 川芎嗪 肺纤维化 CTGF 胶原沉积 |
Effect of Ligustrazine on CTGF Expression and Collagen Deposition in the Pulmonary Fibrosis in Rats |
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| JIANG Yin,LI Wen,CHEN Min.Effect of Ligustrazine on CTGF Expression and Collagen Deposition in the Pulmonary Fibrosis in Rats[J].Applied Journal Of General Practice,2008,6(12):1215-1216. |
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| Authors: | JIANG Yin LI Wen CHEN Min |
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| Abstract: | Objective To observe the effect of ligustrazine on connective tissue growth factor(CTGF)expression and collagen deposition in pulmonary fibrosis rats.Methods 72 male Sprague-Dawley rats were randomly divided into normal control(A group),model group(B group),ligustrazine treatment group(C group),24 rats in each group.Rats were injected with a single dose of bleomycin by trachea to build modes.To observe collagen deposition in rats,the lung was incised to make pathological sections which were stained with Mas... |
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| Keywords: | Ligustrazine Pumlonary fibrosis CTGF Collagen deposition |
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