| 常见的前列腺癌基因和抑癌基因研究进展 |
| |
| 引用本文： | 翁秀华,翁绳美,林菁.常见的前列腺癌基因和抑癌基因研究进展[J].医学综述,2006,12(10):614-616. |
| |
| 作者姓名： | 翁秀华 翁绳美 林菁 |
| |
| 作者单位： | 福建医科大学药学院,福州,350004 |
| |
| 摘 要： | 前列腺癌发生发展与多种基因的异常表达有关,其癌变的形成和发展与多种癌基因的激活和抑癌基因的失活或缺失密切相关。本文综述了几种与前列腺癌关系密切的癌基因和抑癌基因的作用机制,癌基因主要有bcl-2基因、c-myc基因r、as基因、HER-2/neu、前列腺癌诱导基-因1(PTI-1)和HPG1等6种癌基因;抑癌基因包括PTEN、p16、p53、Rb、KLF6和RASSFIA等6种抑癌基因。这些癌基因和抑癌基因在前列腺癌发展过程中的表达量的变化和肿瘤分级、预后相关。
|
| 关 键 词： | 前列腺癌 癌基因 抑癌基因 |
| 文章编号： | 1006-2084（2006）10-0614-03 |
| 收稿时间： | 2005-08-21 |
| 修稿时间： | 2006-03-02 |
Progress of Oncogene and Anti-oncogene of Prostatic Cancer |
| |
| WENG Xiu-hua,WENG Sheng-mei,LIN Jing.Progress of Oncogene and Anti-oncogene of Prostatic Cancer[J].Medical Recapitulate,2006,12(10):614-616. |
| |
| Authors: | WENG Xiu-hua WENG Sheng-mei LIN Jing |
| |
| Institution: | The College of Pharmacy, Fujian Medical University, Fuzhou 350004. China |
| |
| Abstract: | The abnormal expression of a lot of genes may play an important role in the occurrence and development in prostate cancer. The occurrence and development of prostate cancer was correlated with activation of onengene and inactivation of anti-oncngane. This article reviews the mechanism of several oncegenes including bcl-2 gene,c-myc gene,ras gene,HER-2/neu gene,PTI- 1 gene and HPG1 gene and anti-oncogenes including PTEN gene,p16 gene, p53 gene,Rb gene,KLF6 gene and RASSFIA gene retated to prostatic cancer. The quantitative changes of these oneogenes and anti-oncogenes in the development of prostatic cancer is related to its grade and prognosis. |
| |
| Keywords: | Prostatic cancer Oncogene Anti-oncogene |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
