缬沙坦对糖尿病肾病患者血清转化生长因子TGF-β1水平的影响临床观察

目的 探讨缬沙坦对糖尿病肾病患者血清转化生长因子β1（TGF-β1）水平的临床观察。方法 选郑州大学第一附属医院收治216例糖尿病肾病患者作为观察对象,分为110例对照组和106例实验组,用酶联免疫吸附法测定血清TGF-β1水平,并进行组间比较。结果 对照组治疗前后的TGF-β1含量虽有所下降,但无统计学意义,P〉0.05,而实验组在治疗前后的TGF-β1含量有统计学意义,P〈0.05,治疗后的对照组和实验组的TGF-β1含量也有统计学差异,P〈0.05。结论 缬沙坦能抑制TGF-β1的含量,能有效的减缓或控制慢性肾损害,使其在糖尿病肾病中减缓肾小球硬化及肾间质纤维化发挥重要意义。

Effect of valsartan on transforming growth factor beta 1 level in serum of patients with diabetic nephropathy

Objective To investigate the effects of valsartan on Transforming growth factor beta 1（TGF-β1） level in serum of patients with diabetic nephropathy.Methods The hospital treated 216 cases of diabetic nephropathy patients as the research object,110 cases were randomly divided into control group and 106 patients in experiment group,Determination of serum TGF-β1 levels by ELISA,and compared between the two groups.Results The control group before and after treatment of TGF-β 1 levels have declined,but the difference was not statistically significant,P〉 0.05,The experimental group had statistical significance before and after treatment with TGF-β 1 levels,P〈0.05,After treatment of the control group and the experimental group of TGF-β 1 levels have significant difference,P〈0.05.Conclusion Valsartan can inhibit the content of TGF-β1,which can effectively reduce or control of chronic renal damage in diabetic nephropathy,which slows down the glomerular sclerosis and renal interstitial fibrosis play an important role.