| 血清低密度脂蛋白特异性循环免疫复合物的测定及其临床意义 |
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| 引用本文： | 温玫 王拥军. 血清低密度脂蛋白特异性循环免疫复合物的测定及其临床意义[J]. 临床检验杂志, 2000, 18(1): 1-3 |
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| 作者姓名： | 温玫 王拥军 |
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| 作者单位： | 首都医科大学宣武医院,神经内科实验室,北京100053 |
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| 基金项目： | 北京市科技新星计划基金，北京市优秀青年知识分子基金 |
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| 摘 要： | 为了建立血清低密度脂蛋白（ＬＤＬ）循环免疫复合物（ＬＤＬ－ＣＩＣ）的测定方法。利用酶联免疫吸附试验技术，以羊抗人ＩｇＧ作包板以识别ＣＩＣ中的抗体部分，以兔抗人ＬＤＬ作酶标物识别ＣＩＣ中的抗原部分。研究显示动脉粥样硬化病人血中的ＬＤＬ－ＣＩＣ明显高于对照组，ＬＤＬ－ＣＩＣ水平与血中ＬＤＬ以及其他修饰型ＬＤＬ含量无关。结果表明，该方法简便、稳定、ＬＤＬ－ＣＩＣ作为相对独立的危险因素参与了动脉粥样硬化的
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| 关 键 词： | 低密度脂蛋白 循环免疫复合物 动脉粥样硬化 |
The determination and clinical significance of low density lipoprotein circulating immune complex |
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| WEN Mei. The determination and clinical significance of low density lipoprotein circulating immune complex[J]. Chinese Journal of Clinical Laboratory Science, 2000, 18(1): 1-3 |
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| Authors: | WEN Mei |
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| Abstract: | The technique to determinafion of low density lipoprotein circulating immune complex(LDL CIC)was established with enzyme linked immunosorbent assay(ELISA).The antibody portion of LDL CIC was recognized by goat anti human IgG antibody,and antigen portion of LDL CIC was recognized by rabbit anti human LDL antibody.The technique was simple and stable.It is found that the LDL CIC levels were higher in the patients with carotid atherosclerosis than in controls,and the LDL CIC levels were not related with blood LDL and other modificated LDL.The results suggest that the LDL CIC is involved in the pathogenesis of atherosclerosis. |
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| Keywords: | low density lipoprotein circulating immune complex enzyme linked immunosorbent assay atherosclerosis |
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